Results 41 to 50 of about 457,059 (295)

Climbing down Gaussian peaks [PDF]

, 2015
How likely is the high level of a continuous Gaussian random field on an Euclidean space to have a "hole" of a certain dimension and depth? Questions of this type are difficult, but in this paper we make progress on questions shedding new light in ...
Adler, Robert, Samorodnitsky, Gennady
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Sport climbing competence is influenced by training frequency, experience, self-efficacy, flow, and emotional intelligence

Frontiers in Psychology
Sport climbing requires the integration of physical and cognitive abilities. The Embodied Cognition (EC) theoretical framework is increasingly applied in recreational sport research, as it emphasizes the influence of bodily experience on cognition ...
Marina Turchetto, Valentina Tomaselli, Francesca Giorgi, Silvia Leone, Irene Leo   +4 more
doaj   +1 more source

ClimbAR - An Arkansas Rock Climbing Documentary [PDF]

, 2017
The goal of this thesis project, ‘ClimbAR’ - a rock climbing documentary - is to tell the story of a fringe sport/outdoor activity in the state of Arkansas.
Henkel, Daniel Alan
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Affordance Realization in Climbing: Learning and Transfer

Frontiers in Psychology, 2018
The aim of this study was to investigate how the affordances of an indoor climbing wall changed for intermediate climbers following a period of practice during which hold orientation was manipulated within a learning and transfer protocol.
Ludovic Seifert, Dominic Orth, Bruno Mantel, Jérémie Boulanger, Romain Hérault, Matt Dicks   +5 more
doaj   +1 more source

Climbing behavior by mice as an endpoint for preclinical assessment of drug effects in the absence and presence of pain

Frontiers in Pain Research, 2023
This study evaluated climbing in mice as a tool to assess the expression and treatment of pain-related behavioral depression in male and female ICR mice.
Edna J. Santos, Arianna N. Giddings, Farah A. Kandil, S. Stevens Negus   +3 more
doaj   +1 more source

Intelligent Network Management and Functional Cerebellum Synthesis [PDF]

, 1989
Transdisciplinary modeling of the cerebellum across histology, physiology, and network engineering provides preliminary results at three organization levels: input/output links to central nervous system networks; links between the six neuron populations ...
Loebner, Egon E.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source