Results 41 to 50 of about 156,233 (296)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Physiological demands of indoor wall climbing in children [PDF]
, 2015 The study aimed to assess the physiological demands of indoor wall climbing in children. Twenty five children (aged 8–12 years) from a climbing school, with a performance RP (red point) of IV to V+ UIAA (Union Internationale des Associations d’Alpinisme)
Baláš, Jiří +3 more
core +1 more source
Affordance Realization in Climbing: Learning and Transfer
Frontiers in Psychology, 2018 The aim of this study was to investigate how the affordances of an indoor climbing wall changed for intermediate climbers following a period of practice during which hold orientation was manipulated within a learning and transfer protocol.
Ludovic Seifert +5 more
doaj +1 more source
Frontiers in Pain Research, 2023 This study evaluated climbing in mice as a tool to assess the expression and treatment of pain-related behavioral depression in male and female ICR mice.
Edna J. Santos +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Sport and adventure in the Pădurea Craiului Mountains [PDF]
GeoSport for Society, 2019 The term of tourist product, as it was understood in the first decade after December, has undergone an important change of meaning, in the age of today’s tourist.
Varodi Mihaela OLĂU +3 more
doaj +1 more source
Kinematics and Aerodynamics of Dragonflies (Pantala flavescens, Libellulidae) in Climbing Flight
Frontiers in Bioengineering and Biotechnology, 2022 This study presents a detailed analysis of dragonflies’ climbing flight by integratinghigh-speed photogrammetry, three-dimensional reconstruction, and computational fluid dynamics.
Liansong Peng +7 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Design and development of a pole climbing surveillance robot
, 2011 The cost of installing, monitoring and servicing a fixed camera system can be high and not all areas are in need of constant surveying. The increase in crime in urban areas emphasizes the need for a more effective and efficient surveillance system, as a ...
Barlow, Chris +5 more
core +1 more source