Results 51 to 60 of about 156,233 (296)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Tendril, adhesive disc and super adhesive effect of climbing plant [PDF]
, 2008 Understanding the super adhesion mechanism of biological system is of great scientific interest and a prerequisite for bioinspired design of adhesive systems. To investigate the versatile climbing plant requires the development of new methods.
Wenli Deng
core
Morphological characteristics of elite athletes, specializing in speed climbing, climbing and alpinism [PDF]
, 2013 Purpose. The study involved 26 world-class athletes: 10 - speed climbing, 10 - climbing difficulty, 6 - climbers. Age 19-22 years amounted to athletes. Results. Revealed that body length was significantly higher in speed climbing representatives compared
Elena Ryepko (479133)
core +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Hemodynamic and cardiorespiratory predictors of sport rock climbing performance [PDF]
, 2018 Rock climbing performance has been suggested to involve a notable contribution from the aerobic metabolism. Previously it has been shown that forearm oxygenation kinetics can be used to distinguish ability groups and predict red-point sport climbing ...
Garrido, I +13 more
core +1 more source
Virtual climbing: climb in place with four limbs
Frontiers in Virtual RealityThis paper presents the development of a virtual climbing application using commercially available virtual reality (VR) equipment. The application enables users to simulate climbing a virtual wall with their hands and feet while remaining physically grounded.
Takashi Mitsuda, Shoichi Kimura
openaire +1 more source