Results 71 to 80 of about 457,059 (295)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Psychophysiological Response Differences Between Advanced and Beginner Climbers and Fatigue Management

Journal of Functional Morphology and Kinesiology
Background/Objectives: Rock climbing is a multifaceted athletic activity that requires both psychological and physiological resilience. This study aimed to examine the differences in psychological factors and fatigue predictors between novice and ...
Alejandro Padilla-Crespo, Vicente Javier Clemente-Suárez, Álvaro Bustamante-Sánchez   +2 more
doaj   +1 more source

Kasner solutions, climbing scalars and big-bang singularity

, 2013
We elaborate on a recently discovered phenomenon where a scalar field close to big-bang is forced to climb a steep potential by its dynamics. We analyze the phenomenon in more general terms by writing the leading order equations of motion near the ...
Condeescu, Cezar, Dudas, Emilian
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effective Fitness Landscapes for Evolutionary Systems

, 1999
In evolution theory the concept of a fitness landscape has played an important role, evolution itself being portrayed as a hill-climbing process on a rugged landscape.
Stephens, C. R.
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

POTENTIAL IMPACTS OF THE ASIAN CLIMBING PERCH ON QUEENSLAND [PDF]

Risk of establishment of the freshwater climbing perch (Anabas testudineus) in mainland Queensland from the Torres Strait is high. The species is dispersed through human assistance and/or attributes that assist its own spread.
East, Miriam, Micke, Wade
core   +1 more source

Analisis Implementasi Standar Keselamatan dan Pemakaian Peralatan Panjat Tebing untuk Meningkatkan Keselamatan Kerja pada Kegiatan Sport Climbing (Studi pada Fpti Jawa Tengah) [PDF]

, 2013
Broadly speaking, the climbing wall is divided into two: Climbing Natural and Artificial Climbing. Artificial Climbing identical with Sport Climbing or Climbing Achievement commandeered By FPTI (Indonesian Rock Climbing Federation).
Jayanti, M.Sc, dr. Siswi, Lestyanto, M.Si, dr. Daru, Sugiarto, F. P. (Febrina)   +2 more
core