Results 31 to 40 of about 84,817 (240)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Biomechanics of climbing palms and how they climb [PDF]

Plant Signaling & Behavior, 2009
Climbing plants have fascinated botanists since the pioneering works of Darwin and his contemporaries in the 19(th) century. Diverse plants have evolved different ways of climbing and a wide range of attachment devices and stem biomechanics to cope with the particular physical demands of life as a climber. We investigated the biomechanics of attachment
Nick, Rowe, Sandrine, Isnard
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Affordance Realization in Climbing: Learning and Transfer

Frontiers in Psychology, 2018
The aim of this study was to investigate how the affordances of an indoor climbing wall changed for intermediate climbers following a period of practice during which hold orientation was manipulated within a learning and transfer protocol.
Ludovic Seifert, Dominic Orth, Bruno Mantel, Jérémie Boulanger, Romain Hérault, Matt Dicks   +5 more
doaj   +1 more source

Climbing behavior by mice as an endpoint for preclinical assessment of drug effects in the absence and presence of pain

Frontiers in Pain Research, 2023
This study evaluated climbing in mice as a tool to assess the expression and treatment of pain-related behavioral depression in male and female ICR mice.
Edna J. Santos, Arianna N. Giddings, Farah A. Kandil, S. Stevens Negus   +3 more
doaj   +1 more source

Pacific lamprey inspired climbing

Bioinspiration & Biomimetics, 2023
Abstract Snakes and their bio-inspired robot counterparts have demonstrated locomotion on a wide range of terrains. However, dynamic vertical climbing is one locomotion strategy that has received little attention in the existing snake robotics literature.
Brian Van Stratum, Kourosh Shoele, Jonathan E Clark   +2 more
openaire   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Sport and adventure in the Pădurea Craiului Mountains [PDF]

GeoSport for Society, 2019
The term of tourist product, as it was understood in the first decade after December, has undergone an important change of meaning, in the age of today’s tourist.
Varodi Mihaela OLĂU, Dana Ioana CRISTEA , Anca-Cristina POP, Maria GOZNER   +3 more
doaj   +1 more source

Kinematics and Aerodynamics of Dragonflies (Pantala flavescens, Libellulidae) in Climbing Flight

Frontiers in Bioengineering and Biotechnology, 2022
This study presents a detailed analysis of dragonflies’ climbing flight by integratinghigh-speed photogrammetry, three-dimensional reconstruction, and computational fluid dynamics.
Liansong Peng, Tianyu Pan, Mengzong Zheng, Shiying Song, Guanting Su, Qiushi Li, Qiushi Li, Qiushi Li   +7 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source