Results 81 to 90 of about 471,024 (280)

Reliability, Objectivity, Validity, and Reference Levels of the Austrian Pole Climbing Test (APCT)—A Novel Monitoring Tool for Assessing General Fitness in Children, Adolescents, and Young Adults

open access: yesSports
Climbing is an activity involving many major muscle groups and, therefore, it is suitable for assessing general physical fitness. The Austrian pole climbing test (APCT) was developed as a reliable and valid test for the assessment of general fitness ...
Gerald Jarnig   +2 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

The influence of sport climbing on depression and anxiety levels - literature review

open access: yesJournal of Education, Health and Sport, 2018
Introduction: Depression, as one of the most common psychological disorders, which is characterized by anxiety problems, lack of energy, feeling of worthlessness or self-esteem problems affects from 5 to 17% of the population. Despite the fact that it is
Grzegorz Zieliński   +5 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Commentary: Supporting Maternal Mental Health and Nurturing Care in Humanitarian Settings

open access: yesJournal on Education in Emergencies, 2021
Bernadette Daelmans   +5 more
doaj   +1 more source

Genotypic variation in climbing ability traits in a common bean RIL population [PDF]

open access: yes, 2004
Climbing beans are vines that can be grown in either monoculture using wooden or bamboo trellises or in intercropping with other support crops such as maize, but in either case an important characteristic of climbing beans is their vegetative vigor and
Beebe, Steve   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Use of closed chain exercises, eccentric exercises, and proprioceptive muscle facilitation to prevent elbow injuries in climbers: a randomized control trial

open access: yesPhysiotherapy Quarterly, 2022
Serhii Kozin   +6 more
doaj   +1 more source

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