Results 81 to 90 of about 184,986 (360)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Fossil climbing perch and associated plant megafossils indicate a warm and wet central Tibet during the late Oligocene

Scientific Reports, 2017
Understanding the Tibetan Plateau’s palaeogeography and palaeoenvironment is critical for reconstructing Asia’s climatic history; however, aspects of the plateau’s uplift history remain unclear.
Feixiang Wu, Desui Miao, Mee-mann Chang, G. Shi, Ning Wang   +4 more
semanticscholar   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Motion Analysis of the Wrist and Finger Joints in Sport Climbing

Bioengineering
Climbing is a fast-growing sport, with one of the most common injuries being a rupture of the finger flexor tendon pulley. The strain on pulleys increases as finger joints flex.
Gabriella Fischer, Micha Schneeberger, Stefan Andreas Petter, Anne-Gita Scheibler, Peter Wolf, Maurizio Calcagni, Andreas Schweizer, Lisa Reissner   +7 more
doaj   +1 more source

Risk and Lifestyle Sports: The Case of Bouldering

Entertainment and Sports Law Journal, 2017
The recent case of Maylin v Dacorum Sports Trust [2017] EWHC 378 (QB) is the latest example of a claim being made for damages suffered whilst participating in bouldering, a form of low-level climbing.
Guy Osborn, Paul Gilchrist
doaj   +2 more sources

Climbing [PDF]

, 2020
Climbing has come a long way since its inception by Victorian mountaineers and local guides in the European Alps. This chapter provides more information on climbing as competitive sport and its popularity in Japan.
openaire   +3 more sources

Modified hill climbing MPPT algorithm with reduced steady‐state oscillation and improved tracking efficiency

Jurnal Engineering, 2018
To ensure the photovoltaic (PV) system can still output maximum power under changing environmental conditions, a modified hill climbing algorithm is proposed.
Weiwei Zhu, Li-qun Shang, Pengwei Li, Hangchen Guo   +3 more
semanticscholar   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Commentary: Supporting Maternal Mental Health and Nurturing Care in Humanitarian Settings

Journal on Education in Emergencies, 2021
Bernadette Daelmans, Mahalakshmi Nair, Fahmy Hanna, Ornella Lincetto, Tarun Dua, Xanthe Hunt   +5 more
doaj   +1 more source