Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S. +12 more
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Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
How Did the COVID-19 Pandemic Affect the Clinical Skills and Competencies Among New General Physicians: A Qualitative Study [PDF]
Background: Amidst the COVID-19 crisis, many new general physicians who were medical interns during the pandemic were deprived of clinical rotations, new learning situations, and educational opportunities.
Bita Badri +4 more
doaj +1 more source
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann +8 more
wiley +1 more source
Clinical Psychology Today Vol 3 Issue 2 (Winter 2019) [PDF]
'Clinical Psychology Today' a journal for Clinical Psychologists to share research, practice and exchange views on the science and practice of Clinical Psychology.
Collins, Padraig
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Competences of Clinical Psychologists [PDF]
Background: Politicians, societies, stakeholders, health care systems, patients, their relatives, their employers, and the general population need to know what they can expect from clinical psychologists.
ACLIPT Task Force On "Competences of Clinical Psychologists" +2 more
core +1 more source
Demographic and clinical correlates of depression among older adults with arthritis in Nigeria
Background: Older adults have a high prevalence of chronic conditions like arthritis with morbidities, especially depression ranging up to 40% – 70%. Therefore, it is important to explore depression in older adults with arthritis.
Yesiru A. Kareem +6 more
doaj +1 more source
Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari +5 more
wiley +1 more source
Perception of Phase I MBBS Students on the Early Clinical Exposure Module in Anatomy: A Cross-sectional Study [PDF]
Introduction: Early Clinical Exposure (ECE) is an innovative approach in medical education that introduces MBBS students to patient care from the very beginning of their studies.
Anil Kumar Dwivedi, Niyati Airan
doaj +1 more source
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source

