Results 101 to 110 of about 5,362,679 (291)

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

SUSCEPTIBILITY OF Listeria monocytogenes STRAINS ISOLATED FROM FOOD TO ANTIMICROBIAL AGENTS

Italian Journal of Food Safety, 2013
The objective of this study was to evaluate the susceptibility of 40 L. monocytogenes strains isolated from seafood and processing environments to 19 antibiotics currently used in veterinary and human therapy.
E. Zanardi, S. Ghidini, A. Ianieri, M. Conter, A. Mureddu, D. Paludi   +5 more
doaj   +1 more source

Kidney Function Trajectories With Mechanical Circulatory Support

Kidney International Reports
Introduction: Adverse long-term kidney outcomes with left ventricular assist devices (LVADs) are common but little understood. Creatinine-based estimated glomerular filtration rate (eGFR) is used clinically in this setting; however, it is of uncertain ...
Carl P. Walther, Harveen K. Lamba, Ajith P. Nair, Andrew B. Civitello, Nandan K. Mondal, Kenneth K. Liao, Sankar D. Navaneethan   +6 more
doaj   +1 more source

BHAMSLE: A Breakpoint Heuristic Algorithm for Maximum Simulated Likelihood Estimation of Advanced Discrete Choice Models [PDF]

Maximum simulated likelihood estimation (MSLE) is inherently complex due to the presence of multiple local maxima, which hinder standard optimization methods.
Haering, Tom, Bierlaire, Michel
core   +1 more source

Long‐Read Pan‐Cancer Transcriptomics Unravel Distinct Alteration Trends Between Gene and Isoform Expression in Tumorigenesis

iMetaMed, EarlyView.
Long‐read profiling of 144 tumor‐normal pairs identifies isoform‐level cancer dysregulation independent of gene changes. Our scoring system prioritizes isoform‐driven prognostic genes across cancers. ABSTRACT Tumorigenesis involves transcriptomic alterations at both gene and isoform levels.
Yuying Ding, Bo Wu, Dan Zhou, Qiang Li, Dingru Li, Mengyun Cai, Zhiyan Chen, Caimei Zhong, ChuanLe Xiao, Yuhua Deng   +9 more
wiley   +1 more source

Assessment of long-read strategies for the enrichment of clinically relevant breakpoints in lymphomas: towards a diagnostic implementation

Annals of Hematology
Recurrent chromosomal translocations are hallmarks of many hematological malignancies, including lymphomas and leukemias. Accurate breakpoint detection is essential for diagnostics, treatment optimization, and disease monitoring.
Filip Pardy, Kamila Reblova, Hana Svozilova, Boris Tichy, Sarka Pospisilova, Jana Kotaskova, Veronika Navrkalova   +6 more
doaj   +1 more source

Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia

Haematologica, 2013
Deletion of the Ikaros (IKZF1) gene is an oncogenic lesion frequently associated with BCR-ABL1-positive acute lymphoblastic leukemias. It is also found in a fraction of BCR-ABL1-negative B-cell precursor acute lymphoblastic leukemias, and early studies ...
Aurélie Caye, Kheïra Beldjord, Kelly Mass-Malo, Séverine Drunat, Jean Soulier, Virginie Gandemer, André Baruchel, Yves Bertrand, Hélène Cavé, Emmanuelle Clappier   +9 more
doaj   +1 more source

The Pharmacological Management of Cancer Pain in Adults Clinical Audit Tool

, 2016
The audit standards are based on the Pharmacological Management of Cancer Pain in Adults NCEC National Clinical Guideline No. 9. In developing this tool consideration has been given to the clinical issues covered by the guideline and the potential ...
National Clinical Programme for Palliative Care
core  

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Isolated trisomy 7q21.2-31.31 resulting from a complex familial rearrangement involving chromosomes 7, 9 and 10

Molecular Cytogenetics, 2011
Background Genotype-phenotype correlations for chromosomal imbalances are often limited by overlapping effects of partial trisomy and monosomy resulting from unbalanced translocations and by poor resolution of banding analysis for breakpoint designation.
Weimer Jörg, Heidemann Simone, von Kaisenberg Constantin S, Grote Werner, Arnold Norbert, Bens Susanne, Caliebe Almuth   +6 more
doaj   +1 more source