Results 81 to 90 of about 43,064 (280)

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Pre-Use Susceptibility to Ceftaroline in Clinical Staphylococcus aureus Isolates from Germany: Is There a Non-Susceptible Pool to be Selected?

PLoS ONE, 2015
Ceftaroline is a new cephalosporin active against Methicillin-resistant Staphylococcus aureus (MRSA). Based on a representative collection of clinical S.
Birgit Strommenger, Franziska Layer, Ingo Klare, Guido Werner   +3 more
doaj   +1 more source

Detection of structural variants and recurrent breakpoint genes in colorectal adenoma-to-carcinoma progression

, 2017
Background and Aim: The transition of pre-malignant colorectal adenomas (CRAs) into malignant colorectal carcinomas (CRCs) is accompanied by accumulation of somatic genetic alterations.
Voorham, Quirinus J. M., Fijneman, Remond J.A., Carvalho, Beatriz, Evert van den Broek, Sanne Abeln, van de Wiel, Mark A., Quirinus J.M. Voorham, Beatriz Carvalho, Abeln, Sanne; id_orcid, Abeln, Sanne, Gerrit A. Meijer, Meijer, Gerrit A., Dijkstra, Maurits J. J., Remond J.A. Fijneman, van den Broek, Evert, Mark A. van de Wiel, Maurits J.J. Dijkstra   +16 more
core   +1 more source

Phenotypic and Molecular Characterization of Naganishia uzbekistanensis: Diagnostic Challenges and Antifungal Resistance Profile

Journal of Clinical Laboratory Analysis, EarlyView.
The graphical abstract summarizes the laboratory characterization of Naganishia uzbekistanensis strain CY11558. The isolate shows distinct colony morphology, globular yeast cells with a fibrillar surface network under scanning electron microscopy, and a weakly positive cryptococcal antigen reaction.
Xin Fan, Xinfei Chen, Jin Li, Rongchen Dai, Pengjie Hu, Li Gu, Meng Xiao, Xiaomin Yu   +7 more
wiley   +1 more source

ViLR: a novel virtual long read method for breakpoint identification and direct SNP haplotyping in de novo PGT-SR carriers without a proband

Reproductive Biology and Endocrinology
Background Despite the gradual application of third-generation long read sequencing (LRS) or reference embryo establishment to preimplantation genetic testing for structural rearrangement (PGT-SR) without familial involvement, there are still limitations
Jiangyang Xue, Min Xie, Jie Cai, Kai Kang, Mengnan Gu, Mai Li, Haiyue Shi, Xin Zhang, Lingyin Kong, Bo Liang, Liming Zhou, Changshui Chen, Haibo Li   +12 more
doaj   +1 more source

Not Missing the Notch: Detection Challenges of Juxtamembrane NOTCH1 Variant Detection in T‐Cell Acute Lymphoblastic Leukemia

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background Activating mutations in NOTCH1 are frequent in T‐cell acute lymphoblastic leukemia (T‐ALL) and, in the absence of alterations in RAS or PTEN, are associated with favorable prognosis. Besides classical heterodimerization and PEST domain mutations, juxtamembrane internal tandem duplications (JME‐ITDs) represent a third class of ...
Francisco Beas, Stephan Hutter, Ferran Balbastre‐Úbeda, Sandra Novoa‐Jáuregui, Maria Gabarrós‐Subirà, Eulalia Genescà, Petri Pölönen, Torsten Haferlach, Andrés Jerez   +8 more
wiley   +1 more source

[Susceptibility to fluconazole of clinical interest yeasts: new breakpoints].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2013
Recently, Pfaller et al (Drug Resist Update 2010; 13:180-95), have proposed new breakpoints for determining the in vitro susceptibility to fluconazole of Candida albicans, C. parapsilosis and C. tropicalis. The aim of this study was to establish the variations in sensitivity of these species applying these breakpoints, in relation to those of the ...
Lidia, García-Agudo, Pedro, García-Martos, Pilar, Marín-Casanova, Manuel, Rodríguez-Iglesias   +3 more
openaire   +1 more source

On‐site pilot‐scale advanced oxidation pretreatment of hospital wastewater: assessment of pharmaceuticals, pathogens, antibiotic resistance genes and acute ecotoxicity

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Hospital premises generate wastewater containing a wide spectrum of contaminants, such as pharmaceutically active compounds (PhACs), antibiotic resistance genes (ARGs) and pathogenic microorganisms, whilst plenty of them are classified under the antibiotic resistant bacteria (ΑRΒ) category.
Andreas Kaliakatsos, Iosifina Gounaki, Spyros Dokianakis, Georgios Gkotsis, Maria‐Christina Nika, Eleni Aleiferi, Athanasios S Stasinakis, Nikos Katsarakis, Nikolaos S Thomaidis, Thrassyvoulos Manios, Michalis S Fountoulakis, Danae Venieri   +11 more
wiley   +1 more source

Clinical breakpoint changes and their impact on surveillance of antimicrobial resistance in Escherichia coli causing bacteraemia

, 2012
Dutch laboratories are currently changing their breakpoint criteria from mostly Clinical Laboratory and Standards Institute (CLSI) breakpoints to European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints.
Muilwijk, J., Thijsen, S.F.T., van de Sande-Bruinsma, N., Thijsen, S. F.T., van Dijk, K., Notermans, D.W., Notermans, D. W., de Greeff, S., Van der Bij, A. K., van der Bij, A.K.   +9 more
core   +1 more source

The impact of a vancomycin intervention on vancomycin‐associated nephrotoxicity in children: a quality improvement initiative

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Vancomycin is first‐line treatment for methicillin‐resistant Staphylococcus aureus (MRSA) infections. However, despite guideline recommendations, there is no evidence that targeting vancomycin trough concentrations of ≥15 mg/L in children confers clinical benefit and is associated with vancomycin‐associated nephrotoxicity (VAN ...
Megan R. Nettleton, Hwi‐Eun Mary Shim, Joanne Abbotsford, Zoy Goff, Briony Hazelton, Matthew O'Brien, Tenielle Porter, Thomas Snelling, Daniel K. Yeoh, Asha C. Bowen, Christopher C. Blyth, Anita J. Campbell   +11 more
wiley   +1 more source