Results 151 to 160 of about 68,369 (257)

Time Kill Curve PD Modelling Experiments Are Affected by Trailing MIC Endpoints: Refinement of MIC Determination for S. pseudintermedius

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Trailing endpoints are a recognised challenge in broth microdilution MIC testing, particularly for bacteriostatic agents such as trimethoprim (TMP) and sulphonamides. In this study, we applied a pharmacodynamically guided refinement to determine the MIC of the combination against Staphylococcus pseudintermedius; we did not aim at redefining ...
Andrew Mead, Ludovic Pelligand
wiley   +1 more source

Fosmidomycin for the Treatment of Canine Otitis Externa: A Randomised, Double‐Blinded, Controlled ‘Split Body’ Clinical Trial

Veterinary Dermatology, EarlyView.
ABSTRACT Background Targeted antimicrobial therapy for canine otitis externa (OE) represents an opportunity for antimicrobial stewardship. Fosmidomycin selectively inhibits the non‐mevalonate pathway for isoprenoid biosynthesis utilised by canine‐adapted, and not human‐adapted, staphylococci.
Lindsey E. Citron, Darko Stefanovski, Youwen You, Rachel Proctor, Donna Watson, Julie Randall, Christine L. Cain   +6 more
wiley   +1 more source

Prevalence and Relatedness of Salmonella in the Environments of Livestock Markets Handling Surplus Dairy Calves

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Livestock markets are critical hubs within animal trade networks that influence pathogen dissemination at the regional and national scale. Indeed, a 2016 Salmonella serovar Heidelberg outbreak, initially linked to surplus dairy calves at livestock markets, sickened 63 people across 17 states.
Samantha R. Locke, Daysia Reese, Rachel Meyer, Jessica Pempek, Don Sockett, Nicole Aulik, Gregory Habing   +6 more
wiley   +1 more source

Sex differences in loop gain measured via superimposed end‐expiratory breath holds and inspired steady‐state hypoxia

Experimental Physiology, EarlyView.
Abstract Acute low oxygen exposure (hypoxia) elicits a hypoxic ventilatory response (HVR), which increases ventilation and mitigates hypoxaemia. During sustained exposure to hypoxia, ventilatory acclimatization increases peripheral chemoreflex (HVR) sensitivity or chemoreflex loop gain (LG).
Benjamin W. L. MacKenzie, Nicole A. Johnson, Nicholas D. J. Strzalkowski, Trevor A. Day   +3 more
wiley   +1 more source

Association between the NHHR and hepatic steatosis and liver fibrosis: a population-based study

Scientific Reports
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with dyslipidemia, and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a more comprehensive indicator of lipids.
Xiaoxian Yang, Haiyi Yan, Rui Guo, Yan Chen   +3 more
doaj   +1 more source

Frequency responses of human magnetophosphene perception thresholds during dark adaptation point to rod modulation

Experimental Physiology, EarlyView.
Abstract Magnetophosphenes are flickering lights perceived when an extremely low frequency magnetic field generates a sufficiently strong electric field in the head. Understanding how phosphenes are produced is crucial, as they form the basis for international safety standards and guidelines for both workers and the general population.
Nicolas Bouisset, Andres Carvallo, Sebastien Villard, Ilkka Laakso, Alexandre Legros   +4 more
wiley   +1 more source

Validation of muscle oxygenation kinetics to predict aerobic fitness and exercise transition thresholds

Experimental Physiology, EarlyView.
Abstract The aim of this study was to validate previously developed equations to predict maximal oxygen uptake (V̇O2max${\dot V_{{{\mathrm{O}}_{\mathrm{2}}}{\mathrm{max}}}}$) from near‐infrared spectroscopy (NIRS) during and after a period of limb ischaemia.
Heru Syarli Lesmana, Ben Schroeder, Kyohei Marume, Patrick Rodrigues, Justin S. Lawley   +4 more
wiley   +1 more source

Teledermatology Exposes a Neglected Endemic: The Hidden Burden of Tinea Imbricata in Eastern Indonesia

International Journal of Dermatology, EarlyView.
Livia Ayuni, Maria Harianja, Messe R. Ataupah, Ruth D. Laiskodat, Jochem Buil, Claus Bøgh, Hardyanto Soebono, Marlous L. Grijsen   +7 more
wiley   +1 more source

The role of acid‐base balance in cerebrovascular and ventilatory responses to CO2 during 10 h normobaric hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend During 10 h exposures to normobaric hypoxia exposure there was a selective leftward shift in ventilatory response to hyperoxic hypercapnic rebreathing, but not the cerebrovascular response. The key findings are that the resetting of the central chemoreflex to lower PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_2}}}$ during early hypoxic ...
Holly Barclay, Saptarshi Mukerji, Bengt Kayser, Jui‐Lin Fan   +3 more
wiley   +1 more source

Genomic signature driving preinvasive to invasive processes in stage I lung adenocarcinoma

International Journal of Cancer, Volume 158, Issue 7, Page 1975-1988, 1 April 2026.
What's new? The progression of lung cancer from minimally invasive adenocarcinoma (MIA) to invasive adenocarcinoma (IA) is a complex process involving molecular and microenvironment changes. Key molecular events that drive the invasion process, however, remain poorly characterized. In this comparison of gene profiles and differentially mutated genes in
Biqin Mou, Yishan Duan, Jing Wang, Tiantian Li, Yuwei Huo, Xia Xiao, Conghui Cui, Zhujun Deng, Qiongxia Hu, Juan Jiang, Yiwei Liang, Sifen Lu, Xintong Tao, Kang Xie, Xinru Xiong, Niu Zhu, Liyun Bi, Faqiang Zhang, Weimin Li, Bojiang Chen   +19 more
wiley   +1 more source