Results 41 to 50 of about 43,064 (280)

Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints [PDF]

Journal of Antimicrobial Chemotherapy, 2016
To describe the population pharmacokinetics of oral amoxicillin and to compare the PTA of current dosing regimens.Two groups, each with 14 healthy male volunteers, received oral amoxicillin/clavulanic acid tablets on two separate days 1 week apart. One group received 875/125 mg twice daily and 500/125 mg three times daily and the other group 500/125 mg
de Velde, Femke; de Winter, Brenda C. M.; Koch, Birgit C. P.; van Gelder, Teun; Mouton, Johan W.   +5 more
openaire   +3 more sources

15q Duplication Syndrome: Report on the First Patient from Ecuador with an Unusual Clinical Presentation

Case Reports in Medicine, 2021
Background. The 15q11.1-13.1 duplication, also known as Dup15q syndrome, is a rare congenital disease affecting 1 in 30,000 to 1 in 60,000 children worldwide.
Esteban Ortiz-Prado, Ana Lucía Iturralde, Katherine Simbaña-Rivera, Lenin Gómez-Barreno, Iván Hidalgo, Mario Rubio-Neira, Nicolás Espinosa, Juan Izquierdo-Condoy, María Emilia Arteaga-Espinosa, Alex Lister, Andrés López-Cortés, Alejandro Cabrera-Andrade   +11 more
doaj   +1 more source

Validation of a novel medium for drug susceptibility testing of Mycobacterium Tuberculosis against First- and Second-Line drugs: AYC.2.2 Agar and AYC.2.1 Broth

International Journal of Mycobacteriology, 2021
Background: The aim of this study was the validation of AYC.2.2 agar and AYC.2.1 broth for the breakpoint values of first- and second-line drugs for Mycobacterium tuberculosis.
Ahmet Yilmaz Coban
doaj   +1 more source

Efficient CNV breakpoint analysis reveals unexpected structural complexity and correlation of dosage-sensitive genes with clinical severity in genomic disorders

, 2017
Genomic disorders are the clinical conditions manifested by submicroscopic genomic rearrangements including copy number variants (CNVs). The CNVs can be identified by array-based comparative genomic hybridization (aCGH), the most commonly used technology
Ling Zhang, Haoran Ji, Zhang, Cheng, Claudia M.B. Carvalho, Yuwu Jiang, Wu, Xiru, Xiru Wu, Weichen Zhou, Wang, Jingmin, Zhou, Weichen, Yang Luo, Ji, Haoran, Lupski, James R., Zhang, Ling, Jin, Li, Carvalho, Claudia M. B., Zhang, Feng, Li, Dongxiao, Dongxiao Li, Wu, Ye, Jingmin Wang, Ye Wu, Jiang, Yuwu, Jianqiu Xiao, Xiao, Jianqiu, Luo, Yang, Li Jin, James R. Lupski, Feng Zhang, Wang, Hongyan, Cheng Zhang, Hongyan Wang   +31 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Antimicrobial susceptibility of 6 antimicrobial agents in Helicobacter pylori clinical isolates by using EUCAST breakpoints compared with previously used breakpoints

Enfermedades Infecciosas y Microbiología Clínica, 2017
The aim of this study was to determine the differences in percentage resistance in H. pylori clinical isolates using EUCAST breakpoints compared with previously used breakpoints. MIC value distribution in H. pylori clinical isolates was also studied.Susceptibility to amoxicillin, tetracycline, metronidazole, clarithromycin, rifampicin and levofloxacin ...
Alarcón Cavero, Teresa, Urruzuno, Pedro, Martínez, María Josefa, Domingo, Diego, Llorca, Laura, Correa, Ana, López-Brea, Manuel   +6 more
openaire   +2 more sources

Meropenem susceptibility breakpoint for Pseudomonas aeruginosa strains hyperproducing mexB mRNA

, 2005
Twenty-five isolates of Pseudomonas aeruginosa with different meropenem susceptibilities were subjected to quantitative RT-PCR for analysis of transcription levels of oprD, mexB and mexD, and, in selected isolates, PA3720, which is hyper-expressed in ...
Borén, C., B. Wretlind, G. Kronvall, Kronvall, G,, Giske, C.G., C.G. Giske, Wretlind, B., Kronvall, G., Borén, C, C. Borén, Giske, CG, Wretlind, B   +11 more
core   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Atypical BCR-ABL mRNA transcripts in adult Acute lymphoblastic leukemia

Haematologica, 2007
RT-PCR detects chimeric BCR-ABL mRNA in approximately 25% of adult acute lymphoblastic leukemia (ALL) cases. Minor breakpoint transcripts (e1a2) are found in about 70% of positive cases and major breakpoint transcripts (e13a2, e14a2) in about 30% of ...
Thomas Burmeister, Stefan Schwartz, Almut Taubald, Edgar Jost, Thomas Lipp, Folker Schneller, Helmut Diedrich, Henrike Thomssen, Ulrich J.M. Mey, Jan Eucker, Harald Rieder, Nicola Gökbuget, Dieter Hoelzer, Eckhard Thiel   +13 more
doaj   +1 more source

Phenotypic and Genotypic Correlates of Penicillin Susceptibility in Nontoxigenic Corynebacterium diphtheriae, British Columbia, Canada, 2015–2018

Emerging Infectious Diseases, 2020
In 2015, the Clinical and Laboratory Standards Institute (CLSI) updated its breakpoints for penicillin susceptibility in Corynebacterium species from
Jason Zou, Samuel D. Chorlton, Marc G. Romney, Michael Payne, Tanya Lawson, Anna Wong, Sylvie Champagne, Gordon Ritchie, Christopher F. Lowe   +8 more
doaj   +1 more source