Results 31 to 40 of about 43,064 (280)

A proposal of clinical breakpoints for amoxicillin applicable to porcine respiratory tract pathogens [PDF]

Veterinary Microbiology, 2008
In the present position paper, an attempt was made to establish clinical breakpoints of amoxicillin to classify porcine respiratory tract pathogens as susceptible, intermediate or resistant based on their minimum inhibitory concentrations of amoxicillin.
Stefan, Schwarz, Alexander, Böttner, Luc, Goossens, Luc, Goosens, H Mohamed, Hafez, Katrin, Hartmann, Martin, Kaske, Corinna, Kehrenberg, Manfred, Kietzmann, Dieter, Klarmann, Günter, Klein, Peter, Krabisch, Gabriele, Luhofer, Angelika, Richter, Bianka, Schulz, Claudia, Sigge, Karl-Heinz, Waldmann, Jürgen, Wallmann, Christiane, Werckenthin   +18 more
openaire   +3 more sources

Pharmacodynamics of isavuconazole in experimental invasive pulmonary aspergillosis: implications for clinical breakpoints [PDF]

Journal of Antimicrobial Chemotherapy, 2016
Isavuconazole, a novel triazole antifungal agent, has broad-spectrum activity against Aspergillus spp. and other pathogenic fungi. The isavuconazole exposure-response relationship in experimental invasive pulmonary aspergillosis using galactomannan index (GMI) suppression as a marker of disease clearance was explored.The impact of exposure on GMI ...
Kovanda, Laura L, Petraitiene, Ruta, Petraitis, Vidmantas, Walsh, Thomas J, Desai, Amit, Bonate, Peter, Hope, William W   +6 more
openaire   +2 more sources

Introduction to the Revised International Guidelines on Breakpoints for Antimicrobial Susceptibility Testing [PDF]

Annals of Clinical Microbiology, 2023
Clinical and Laboratory Standards Institute (CLSI) M100 ‘Performance Standards for Antimicrobial Susceptibility Testing (AST)’ and the European Committee on AST (EUCAST) ‘Breakpoint tables for interpretation of MICs and zone diameters’ guidelines for ...
Jae-Woo Chung
doaj   +1 more source

Development of Daptomycin Susceptibility Breakpoints for Enterococcus faecium and Revision of the Breakpoints for Other Enterococcal Species by the Clinical and Laboratory Standards Institute [PDF]

Clinical Infectious Diseases, 2019
Abstract Daptomycin is one of the few treatment options for infections caused by enterococci that are resistant to ampicillin and vancomycin, such as vancomycin-resistant Enterococcus faecium. The emergence and clinical significance of daptomycin-resistant enterococci and evolving microbiologic, pharmacokinetic-pharmacodynamic, and ...
Michael J, Satlin, David P, Nicolau, Romney M, Humphries, Joseph L, Kuti, Shelley A, Campeau, James S, Lewis Ii, Melvin P, Weinstein, James H, Jorgensen   +7 more
openaire   +2 more sources

Intronic Breakpoint Signatures Enhance Detection and Characterization of Clinically Relevant Germline Structural Variants [PDF]

The Journal of Molecular Diagnostics, 2021
The relevance of large copy number variants (CNVs) to hereditary disorders has been long recognized, and population sequencing efforts have chronicled many common structural variants (SVs). However, limited data are available on the clinical contribution of rare germline SVs.
Jeroen van den Akker, Lawrence Hon, Anjana Ondov, Ziga Mahkovec, Robert O'Connor, Raymond C. Chan, Justin Lock, Anjali D. Zimmer, Asha Rostamianfar, Jeremy Ginsberg, Annette Leon, Scott Topper   +11 more
openaire   +2 more sources

Evaluation of urine concentrations of amoxicillin and clavulanate in cats

Journal of Veterinary Internal Medicine, 2021
Background To characterize urinary isolates, the Clinical and Laboratory Standards Institute (CLSI) uses an amoxicillin breakpoint for cats based on plasma (not urine) drug concentrations (≤0.25 μg/mL), but a urine‐specific breakpoint for dogs exists (≤8 
Kate KuKanich, Kallie Woodruff, Zackery Bieberly, Mark G. Papich, Butch KuKanich   +4 more
doaj   +1 more source

Pharmacokinetic–pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses

Frontiers in Microbiology, 2023
IntroductionThe aim of this international project was to establish a species-specific Clinical Breakpoint for interpretation of Antimicrobial Susceptibility Testing of benzylpenicillin (BP) in horses.MethodsA population pharmacokinetic model of BP ...
Elodie A. Lallemand, Alain Bousquet-Mélou, Laura Chapuis, Jennifer Davis, Aude A. Ferran, Butch Kukanich, Taisuke Kuroda, Marlène Z. Lacroix, Yohei Minamijima, Lena Olsén, Ludovic Pelligand, Felipe Ramon Portugal, Béatrice B. Roques, Elizabeth M. Santschi, Katherine E. Wilson, Pierre-Louis Toutain, Pierre-Louis Toutain   +16 more
doaj   +1 more source

Tigecycline Disk Diffusion Breakpoints of Acinetobacter spp.: a Clinical Point of View [PDF]

Journal of Clinical Microbiology, 2007
In the January 2007 issue of the Journal of Clinical Microbiology, Jones et al. reported a multicenter study of the tigecycline disk diffusion breakpoints of Acinetobacter spp., including multidrug-resistant (MDR) strains. The authors concluded that a breakpoint zone diameter of 16/12 mm to define susceptibility/resistance, respectively, instead of ...
Daniel, Curcio, Francisco, Fernández, Ronald N, Jones, Mary Jane, Ferraro, L Barth, Reller, Paul C, Schreckenberger, Helio S, Sader   +6 more
openaire   +2 more sources

Mechanisms for Complex Chromosomal Insertions. [PDF]

PLoS Genetics, 2016
Chromosomal insertions are genomic rearrangements with a chromosome segment inserted into a non-homologous chromosome or a non-adjacent locus on the same chromosome or the other homologue, constituting ~2% of nonrecurrent copy-number gains.
Shen Gu, Przemyslaw Szafranski, Zeynep Coban Akdemir, Bo Yuan, Mitchell L Cooper, Maria A Magriñá, Carlos A Bacino, Seema R Lalani, Amy M Breman, Janice L Smith, Ankita Patel, Rodger H Song, Weimin Bi, Sau Wai Cheung, Claudia M B Carvalho, Paweł Stankiewicz, James R Lupski   +16 more
doaj   +1 more source

DNA topoisomerases participate in fragility of the oncogene RET [PDF]

, 2013
Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
Yuh-Hwa Wang (457429), Dillon, LW, Yuh-Hwa Wang, Christine E. Lehman (457427), Laura W Dillon, Dillon Laura W., Nikiforov Yuri E., Pierce Levi C. T., Wang, YH, Laura W. Dillon (457426), Lehman, Christine E., Christine E Lehman, Lehman, CE, Pierce, Levi C. T., Nikiforov, Yuri E., Pierce, LCT, Yuri E. Nikiforov (457428), Levi C T Pierce, Rybenkov, Valentin V, Wang, Yuh-Hwa, Wang Yuh-Hwa, Levi C. T. Pierce (454414), Lehman Christine E., Yuri E Nikiforov, Dillon, Laura W., Nikiforov, YE   +25 more
core   +1 more source