Results 31 to 40 of about 5,362,679 (291)

Pharmacodynamics of isavuconazole in experimental invasive pulmonary aspergillosis: implications for clinical breakpoints [PDF]

Journal of Antimicrobial Chemotherapy, 2016
Isavuconazole, a novel triazole antifungal agent, has broad-spectrum activity against Aspergillus spp. and other pathogenic fungi. The isavuconazole exposure-response relationship in experimental invasive pulmonary aspergillosis using galactomannan index (GMI) suppression as a marker of disease clearance was explored.The impact of exposure on GMI ...
Kovanda, Laura L, Petraitiene, Ruta, Petraitis, Vidmantas, Walsh, Thomas J, Desai, Amit, Bonate, Peter, Hope, William W   +6 more
openaire   +2 more sources

A novel approach for determining cancer genomic breakpoints in the presence of normal DNA. [PDF]

PLoS ONE, 2007
CDKN2A (encodes p16(INK4A) and p14(ARF)) deletion, which results in both Rb and p53 inactivation, is the most common chromosomal anomaly in human cancers.
Yu-Tsueng Liu, Dennis A Carson
doaj   +1 more source

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs [PDF]

, 2017
This review describes the pharmacokinetic properties of the systemically administered antileishmanial drugs pentavalent antimony, paromomycin, pentamidine, miltefosine and amphotericin B (AMB), including their absorption, distribution, metabolism and ...
Schellens, Jan H M, Dorlo, Thomas P. C.,, Kip, Anke E., Thomas P. C. Dorlo, Kip, Anke E, Schellens, Jan H. M., Beijnen, Jos H., Beijnen, Jos H.,, Schellens, Jan H. M.,, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Dorlo, Thomas P. C., Dorlo, Thomas P C, Anke E. Kip, Kip, Anke E.,, Jos H. Beijnen, Beijnen, Jos H, Jan H. M. Schellens   +17 more
core   +1 more source

Intronic Breakpoint Signatures Enhance Detection and Characterization of Clinically Relevant Germline Structural Variants [PDF]

The Journal of Molecular Diagnostics, 2021
The relevance of large copy number variants (CNVs) to hereditary disorders has been long recognized, and population sequencing efforts have chronicled many common structural variants (SVs). However, limited data are available on the clinical contribution of rare germline SVs.
Jeroen van den Akker, Lawrence Hon, Anjana Ondov, Ziga Mahkovec, Robert O'Connor, Raymond C. Chan, Justin Lock, Anjali D. Zimmer, Asha Rostamianfar, Jeremy Ginsberg, Annette Leon, Scott Topper   +11 more
openaire   +2 more sources

On the similarity of sets of permutations and its applications to genome comparison [PDF]

, 2003
Bergeron A, Stoye J. On the similarity of sets of permutations and its applications to genome comparison. In: Proc. of COCOON 2003. LNCS. Vol 2697.
Jens Stoye, Bergeron, Anne, Stoye, Jens ; https://orcid.org/, Anne Bergeron   +3 more
core   +1 more source

Mapping breakpoint types: an exploratory study

, 2021
This repository contains the breakpoint types study dataset. Abstract Debugging is a relevant task for finding bugs during software development, maintenance, and evolution.
Petrillo, Fabio, Andreetta Fontana, Eduardo   +1 more
core   +1 more source

Development of Daptomycin Susceptibility Breakpoints for Enterococcus faecium and Revision of the Breakpoints for Other Enterococcal Species by the Clinical and Laboratory Standards Institute [PDF]

Clinical Infectious Diseases, 2019
Abstract Daptomycin is one of the few treatment options for infections caused by enterococci that are resistant to ampicillin and vancomycin, such as vancomycin-resistant Enterococcus faecium. The emergence and clinical significance of daptomycin-resistant enterococci and evolving microbiologic, pharmacokinetic-pharmacodynamic, and ...
Michael J, Satlin, David P, Nicolau, Romney M, Humphries, Joseph L, Kuti, Shelley A, Campeau, James S, Lewis Ii, Melvin P, Weinstein, James H, Jorgensen   +7 more
openaire   +2 more sources

Evaluation of urine concentrations of amoxicillin and clavulanate in cats

Journal of Veterinary Internal Medicine, 2021
Background To characterize urinary isolates, the Clinical and Laboratory Standards Institute (CLSI) uses an amoxicillin breakpoint for cats based on plasma (not urine) drug concentrations (≤0.25 μg/mL), but a urine‐specific breakpoint for dogs exists (≤8 
Kate KuKanich, Kallie Woodruff, Zackery Bieberly, Mark G. Papich, Butch KuKanich   +4 more
doaj   +1 more source

Pharmacokinetic–pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses

Frontiers in Microbiology, 2023
IntroductionThe aim of this international project was to establish a species-specific Clinical Breakpoint for interpretation of Antimicrobial Susceptibility Testing of benzylpenicillin (BP) in horses.MethodsA population pharmacokinetic model of BP ...
Elodie A. Lallemand, Alain Bousquet-Mélou, Laura Chapuis, Jennifer Davis, Aude A. Ferran, Butch Kukanich, Taisuke Kuroda, Marlène Z. Lacroix, Yohei Minamijima, Lena Olsén, Ludovic Pelligand, Felipe Ramon Portugal, Béatrice B. Roques, Elizabeth M. Santschi, Katherine E. Wilson, Pierre-Louis Toutain, Pierre-Louis Toutain   +16 more
doaj   +1 more source

Volatility changes between pre-breakpoint and post-breakpoint of 13 Australian sectors using the wavelet approach.

, 2023
Volatility changes between pre-breakpoint and post-breakpoint of 13 Australian sectors using the wavelet approach.
Duc Hong Vo (10515374)
core   +1 more source