Results 11 to 20 of about 5,362,679 (291)

Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma [PDF]

Radiology and Oncology, 2023
t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2.
Panjan Matej, Boltezar Lucka, Novakovic Srdjan, Kokovic Ira, Jezersek Novakovic Barbara   +4 more
doaj   +5 more sources

Clinical Impact of Revised Ciprofloxacin Breakpoint in Patients with Urinary Tract Infections by Enterobacteriaceae [PDF]

Antibiotics, 2021
In 2018, the Clinical and Laboratory Standards Institute (CLSI) revised ciprofloxacin (CIP)-susceptible breakpoint for Enterobacteriaceae from ≤1 μg/mL to ≤0.25 μg/mL, based on pharmacokinetic-pharmacodynamic (PK-PD) analysis.
Ga Eun Park, Jae-Hoon Ko, Sun Young Cho, Hee Jae Huh, Jin Yang Baek, Kwan Soo Ko, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck   +8 more
doaj   +4 more sources

Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes. [PDF]

PLoS ONE, 2010
Mitochondrial DNA (mtDNA) deletions are a common cause of mitochondrial disorders. Large mtDNA deletions can lead to a broad spectrum of clinical features with different age of onset, ranging from mild mitochondrial myopathies (MM), progressive external ...
Bekim Sadikovic, Jing Wang, Ayman W El-Hattab, Megan Landsverk, Ganka Douglas, Ellen K Brundage, William J Craigen, Eric S Schmitt, Lee-Jun C Wong   +8 more
doaj   +5 more sources

Correction: Sequence Homology at the Breakpoint and Clinical Phenotype of Mitochondrial DNA Deletion Syndromes. [PDF]

PLoS ONE, 2017
[This corrects the article DOI: 10.1371/journal.pone.0015687.].
Bekim Sadikovic, Jing Wang, Ayman W El-Hattab, Megan Landsverk, Ganka Douglas, Ellen K Brundage, William J Craigen, Eric S Schmitt, Lee-Jun C Wong   +8 more
doaj   +4 more sources

Clinical Breakpoint of Apramycin to Swine Salmonella and Its Effect on Ileum Flora. [PDF]

Int J Mol Sci, 2022
The purpose of this study was to establish the clinical breakpoint (CBP) of apramycin (APR) against Salmonella in swine and evaluate its effect on intestinal microbiota. The CBP was established based on three cutoff values of wild-type cutoff value (COWT), pharmacokinetic-pharmadynamic (PK/PD) cutoff value (COPD) and clinical cutoff value (COCL).
Dai X, Gu Y, Guo J, Huang L, Cheng G, Peng D, Hao H.   +6 more
europepmc   +4 more sources

Strategy for breakpoint cluster region analysis in chronic myelocytic leukemia in a routine clinical laboratory

American Journal of Clinical Pathology, 1990
Despite the increasing reliance on breakpoint cluster region (bcr) determinations in diagnosis of chronic myelocytic leukemia (CML), few reports have dealt with the practical aspects of specimen analysis. In the setting of a routine molecular diagnostics
Childs, C. C., Trujillo, J. M., Kantarjian, H. M., Cork, A., Haber, L. M., Stass, S. A., Hirsch-Ginsberg, C., Nellis, K.   +7 more
core   +8 more sources

Understanding and Addressing CLSI Breakpoint Revisions: a Primer for Clinical Laboratories [PDF]

Journal of Clinical Microbiology, 2019
The Clinical and Laboratory Standards Institute (CLSI) has revised several breakpoints since 2010 for bacteria that grow aerobically. In 2019, these revisions include changes to the ciprofloxacin and levofloxacin breakpoints for the Enterobacteriaceae and Pseudomonas aeruginosa , daptomycin ...
Romney M, Humphries, April N, Abbott, Janet A, Hindler   +2 more
openaire   +2 more sources

Updated EUCAST Clinical Breakpoints against Aspergillus, Implications for the Clinical Microbiology Laboratory [PDF]

Journal of Fungi, 2020
Azole resistance poses a problem for the management of patients with invasive aspergillosis. Former species are in fact groups of closely related species (or complexes); cryptic species frequently show high antifungal resistance. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) Definitive Document (E.Def) 9.3.2 includes ...
openaire   +4 more sources

Clinical Usefulness of Susceptibility Breakpoints for Yeasts in the Treatment of Candidemia: A Noninterventional Study [PDF]

Journal of Fungi, 2020
This prospective noninterventional study evaluated whether antifungal susceptibility data (MIC) provided for Candida clinical isolates on the basis of recently established breakpoints are taken into account by clinicians to guide their treatment decision making process, and assessed the response in MIC- and non-MIC-based treatment groups.
Cornelia Lass-Flörl, Robert Krause, Birgit Willinger, Peter Starzengruber, Petra Decristoforo, Sabrina Neururer, Peter Kreidl, Maria Aigner   +7 more
openaire   +3 more sources

Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer

BMC Medicine, 2022
Background Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role of exonic breakpoints remains elusive.
Weihua Li, Rui Wan, Lei Guo, Geyun Chang, Dong Jiang, Lin Meng, Jianming Ying   +6 more
doaj   +1 more source