Results 21 to 30 of about 43,064 (280)
BMC Medicine, 2022 Background Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role of exonic breakpoints remains elusive.
Weihua Li +6 more
doaj +1 more source
Frontiers in Genetics, 2022 Expanded carrier screening (ECS) has become an increasingly common technique to assess the genetic risks of individuals in the prenatal or preconception period.
Ying Bai +9 more
doaj +1 more source
Establishing Antimicrobial Susceptibility Testing Methods and Clinical Breakpoints for Inhaled Antibiotic Therapy [PDF]
Open Forum Infectious Diseases, 2022 Abstract Inhaled antibiotics are a common and valuable therapy for patients suffering from chronic lung infection, with this particularly well demonstrated for patients with cystic fibrosis. However, in vitro tests to predict patient response to inhaled antibiotic therapy are currently lacking.
Miquel B Ekkelenkamp +5 more
openaire +4 more sources
Pharmacodynamic Thresholds for Beta-Lactam Antibiotics: A Story of Mouse Versus Man
Frontiers in Pharmacology, 2022 Beta-lactams remain a critical member of our antibiotic armamentarium and are among the most commonly prescribed antibiotic classes in the inpatient setting.
Angela V. Berry, Joseph L. Kuti
doaj +1 more source
Clinical Usefulness of Susceptibility Breakpoints for Yeasts in the Treatment of Candidemia: A Noninterventional Study [PDF]
Journal of Fungi, 2020 This prospective noninterventional study evaluated whether antifungal susceptibility data (MIC) provided for Candida clinical isolates on the basis of recently established breakpoints are taken into account by clinicians to guide their treatment decision making process, and assessed the response in MIC- and non-MIC-based treatment groups.
Cornelia Lass-Flörl +7 more
openaire +3 more sources
Biomedicines, 2022 Detection and precise genomic mapping of balanced chromosomal abnormalities in patients with impaired fertility or a clinical phenotype represent a challenge for current cytogenomics owing to difficulties with precise breakpoint localization in the ...
Tatyana V. Karamysheva +10 more
doaj +1 more source
, 2022 Additional file 1: Table S1. The gene panel used in RNA NGS. Table S2. Characteristics of NSCLC patients who underwent DNA NGS. Table S3. Clinicopathological features of NSCLC cases with exonic- or intronic/intergenic/mixed-breakpoint fusions.
Weihua Li (144468) +6 more
core +1 more source
MCG&BA‐Net: Retinal vessel segmentation using multiscale context gating and breakpoint attention
IET Image Processing, 2022 The accurate segmentation of blood vessels plays a crucial role in screening, diagnosis and treatment of multiple diseases. However, current automated segmentation approaches do not pay enough attention to the vascular topology errors (such as mistaking ...
Pengfei Xu +5 more
doaj +1 more source
Clinical Impact of Revised Cefepime Breakpoint in Patients With Enterobacteriaceae Bacteremia
Open Forum Infectious Diseases, 2019 Abstract The impact of the revised Clinical and Laboratory Standards Institute interpretative criteria for cefepime in Enterobacteriaceae remains unclear. We applied the new breakpoint on 644 previously defined cefepime-susceptible Enterobacteriaceae isolates. We found no differences in mortality or microbiological failure, regardless of
Kap Sum Foong +4 more
openaire +3 more sources
A novel approach for determining cancer genomic breakpoints in the presence of normal DNA. [PDF]
PLoS ONE, 2007 CDKN2A (encodes p16(INK4A) and p14(ARF)) deletion, which results in both Rb and p53 inactivation, is the most common chromosomal anomaly in human cancers.
Yu-Tsueng Liu, Dennis A Carson
doaj +1 more source