Results 111 to 120 of about 1,285,183 (288)

Enhancing Clinical Coding Expertise in Indonesia’s National Health Insurance Program

Jurnal Jaminan Kesehatan Nasional
Coding medical records using classification systems can cause inconsistencies, sometimes leading to claim disputes. In January 2021, 440,749 disputed cases were reported, with a total disputed cost amounting to Rp873,111,325,287 for referral healthcare ...
Novianti Br. Gultom, Arisandy Saputra, Dwi Surini, Erwinsyah, Elsa Novelia, Johana, Vernanda Dosiema, Intan Corina, Miranti Ratnafuri, Fallah Adi Wijayanti, Dedy Setyawan, Egar Januar Prakarsa, Sarman Pali'padang, Gilang Yoga Wardanu, Lia Yulianti Surosa, Jack Langenbrunner, John Blake   +16 more
doaj   +1 more source

Manual annotation of narrative patient charts – Finnish experiences related to a multilingual text corpus

Finnish Journal of eHealth and eWelfare, 2019
ASSESS CT project evaluated SNOMED CT use for patient information exchange in EU. Finland was one of the six participating EU states. The Finnish part of the research was conducted in the National Institute for Health and Welfare. The Finnish experiences
Päivi Mäkelä-Bengs, Päivi Hämäläinen, Virpi Kalliokuusi, Riikka Vuokko   +3 more
doaj   +1 more source

The Charlson comorbidity index in registry-based research : which version to use?

, 2017
Background: Comorbidities may have an important impact on survival, and comorbidity scores are often implemented in studies assessing prognosis. The Charlson Comorbidity index is most widely used, yet several adaptations have been published, all using ...
Brusselaers, Nele, Lagergren, Jesper
core   +1 more source

Fidelity Assessment in Community Programs: An Approach to Validating Simplified Methodology. [PDF]

, 2020
Fidelity to intervention protocol is linked to best outcomes for individuals with autism spectrum disorder (ASD; see Boyd & Corley [Autism 5(4):430-441, 2001]; Pellecchia et al.
Chan, Janice C, Chan, Neilson, Dickson, Kelsey S, Stahmer, Aubyn C, Suhrheinrich, Jessica, Wang, Tiffany   +5 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. [PDF]

, 2019
Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Boichard, Amélie, Frampton, Garrett M, Goodman, Aaron, Kurzrock, Razelle, Lippman, Scott, Pham, Timothy V, Tamayo, Pablo, Tsigelny, Igor F, Yeerna, Huwate   +8 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Identifying the optimal search strategy for coronary heart disease patients in primary care electronic patient record systems

Journal of Innovation in Health Informatics, 2009
Objectives General practitioners are increasingly required to practice in a paperless environment and to collect clinical data electronically on electronic patient record (EPR) systems.
Krish Thiru, Peter Donnan, Peter Weller, Frank Sullivan   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source