Results 111 to 120 of about 201,869 (314)
BJA Open, 2022 Background: We previously showed that an ultrasound-guided i.v. catheter insertion (USGIV) simulation-based mastery learning (SBML) curriculum improves the simulated USGIV skills of paediatric anaesthesiologists.
Heather A. Ballard +7 more
doaj
Question Answering based Clinical Text Structuring Using Pre-trained Language Model [PDF]
arXiv, 2019 Clinical text structuring is a critical and fundamental task for clinical research. Traditional methods such as taskspecific end-to-end models and pipeline models usually suffer from the lack of dataset and error propagation. In this paper, we present a question answering based clinical text structuring (QA-CTS) task to unify different specific tasks ...
arxiv
Advanced Science, EarlyView.This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun +23 more
wiley +1 more source
Anatomical Sciences Education, Volume 16, Issue 1, Page 99-115, January/February 2023., 2023 Abstract Prior to the challenges imposed by the Covid‐19 pandemic, anatomy practical sessions at Trinity College Dublin involved eight to 10 students per donor station, rotating between digital learning, anatomical models/osteology, and dissection activities for three hours weekly.
Dearbhla P. Cullinane, Denis S. Barry
wiley +1 more source
Sequential evaluation of general immune competence in cancer patients: Correlation with clinical course [PDF]
, 1975 Frederick R. Eilber +2 more
openalex +1 more source
Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3
Advanced Science, EarlyView.MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi +9 more
wiley +1 more source
Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration
Advanced Science, EarlyView.This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong +17 more
wiley +1 more source
Structural and Biochemical Characterization of a Widespread Enterobacterial Peroxidase Encapsulin
Advanced Science, EarlyView.Encapsulins are self‐assembling bacterial protein compartments loaded with cargo enzymes. The most abundant encapsulin cargo class are Dye‐decolorizing Peroxidases (DyPs). In this study, we structurally and biochemically characterize a DyP encapsulin found in many enterobacteria.
Natalia C. Ubilla‐Rodriguez +2 more
wiley +1 more source
Advanced Science, EarlyView.Aided by FABP5, abnormally elevated asprosin in hepatocytes enters the nucleus, targets and inhibits PPARα binding to the CPT1A promoter, thereby suppressing FAO. Circulating asprosin exacerbates insulin resistance, collectively driving MASLD progression.
Yuan‐Yuan Yu +13 more
wiley +1 more source
Cognitive flexibility in autism: Evidence from young autistic children
Autism Research, Volume 15, Issue 12, Page 2296-2309, December 2022., 2022 Abstract We examined the cognitive flexibility performance of young autistic children and a group of neurotypical peers. Thirty‐six autistic children (72–83 months) and 200 age‐matched typically‐developing children were assessed on the Children's Color Trails Test (CCTT), a semantic and a phonemic verbal fluency task.
Maria Andreou +2 more
wiley +1 more source