Results 91 to 100 of about 628,991 (311)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Couples Adjusting to Multimorbidity: A Dyadic Study on Disclosure and Adjustment Disorder Symptoms

Frontiers in Psychology, 2019
BackgroundMultimorbidity is challenging not only for the patient but also for the romantic partner. Strategies for interpersonal emotion regulation like disclosing to the partner are supposed to play a major role in the psychosocial adjustment to ...
Andrea B. Horn, Andrea B. Horn, Andrea B. Horn, Victoria S. Boettcher, Barbara M. Holzer, Barbara M. Holzer, Klarissa Siebenhuener, Klarissa Siebenhuener, Andreas Maercker, Andreas Maercker, Edouard Battegay, Edouard Battegay, Edouard Battegay, Lukas Zimmerli, Lukas Zimmerli   +14 more
doaj   +1 more source

Examination of a Parent-Assisted, Friendship-Building Program for Adolescents with ADHD [PDF]

, 2015
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common childhood disorder that often contributes to impairment in multiple domains, including peer functioning.
Gardner, Denise Marie
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Post-simulation debriefing as a stepping stone to self-reflection and increased awareness — a qualitative study

Advances in Simulation
Background The voice of the students should be engaged in simulation curriculum development. Involving the students in the development of debriefing strategies might result in a deeper understanding of learning. However, few studies have investigated the
Sissel Eikeland Husebø, Inger Åse Reierson, Anette Hansen, Hilde Solli   +3 more
doaj   +1 more source

A randomized clinical trial comparing family-focused treatment and individual supportive therapy for depression in childhood and early adolescence [PDF]

, 2017
OBJECTIVE: Despite the morbidity and negative outcomes associated with early-onset depression, few studies have examined the efficacy of psychosocial treatment for depressive disorders during childhood.
Asarnow, Joan R., Langer, David A., Sugar, Catherine A., Tompson, Martha C.   +3 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Body site-specific micro- and lactobiota in genitourinary infections during pregnancy

Frontiers in Cellular and Infection Microbiology
BackgroundImmunological, metabolic, and hormonal changes occur during pregnancy, which can affect the composition and function of the microbiota in diverse body sites.
Siiri Kõljalg, Siiri Kõljalg, Siiri Kõljalg, Epp Sepp, Epp Sepp, Jelena Štšepetova, Jelena Štšepetova, Eva-Liina Süüden, Tiia Reimand, Madis Jaagura, Andres Salumets, Andres Salumets, Andres Salumets, Reet Mändar, Reet Mändar   +14 more
doaj   +1 more source

Evaluating medico-legal decisional competency criteria [PDF]

, 2013
In this paper I get clearer on the considerations that ought to inform the evaluation and development of medico-legal competency criteria-where this is taken to be a question regarding the abilities that ought to be needed for a patient to be found ...
Whiting, Demian
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source