Results 151 to 160 of about 599,878 (339)

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

Advanced Science, EarlyView.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin, Yang Ruimeng, Wang Peihong, Liu Xiaohui, Yuan Hao, Huang Hongli, Zhou Yongjian, Xie Baoshu   +7 more
wiley   +1 more source

American College of Cardiology/American Heart Association Clinical Competence Statement on Echocardiography [PDF]

, 2003
Miguel A. Quiñones, Pamela S. Douglas, Elyse Foster, John Gorcsan, Jannet F. Lewis, Alan S. Pearlman, Jack Rychik, Ernesto E. Salcedo, James B. Seward, J. Geoffrey Stevenson, Daniel M. Thys, Alan W. Boone, William A. Zoghbi, Mark A. Creager, William L. Winters, Michael Elnicki, John W. Hirshfeld, Beverly H. Lorell, George P. Rodgers, Cynthia M. Tracy, Alan W. Boone   +20 more
openalex   +1 more source

Managing Madness: The ethics of identifying and treating mental illness [PDF]

, 2019
This essay analyzes different contemporary models for defining mental illness and offers a new framework that promotes the use of normative values during the clinical diagnostic process.
Seely, Mason
core   +1 more source

Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling

Advanced Science, EarlyView.
This study identifies that RBM10 represses the transcriptional activity of RORB in liquid condensates, resulting in down‐regulation of NR1D1 and RIOK3 that further activates NF‐κB activity to facilitate lysosomal biogenesis and aggressive features of NB cells.
Yanhua Guo, Xiaojing Wang, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Jiaying Qu, Shunchen Zhou, Liduan Zheng, Qiangsong Tong   +9 more
wiley   +1 more source

Don\u27t Argue with the Members [PDF]

, 2011
Mel Pollner regularly cautioned researchers not to argue with the members of settings under consideration. He warned against substituting the researcher’s meaning for the meanings of those being studied.
Gubrium, Jaber F, Holstein, James A
core   +1 more source

APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer

Advanced Science, EarlyView.
Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu, Qimei Bao, Hanyi He, Yuke Zhong, Mingcong Deng, Yangchan Hu, Chunkai Zhang, Chen Liang, Yixing Huang, Haidong Liu, Xiao Li, Yanhua He, Guoyan Luo, Weixin Wu, Fenghui Guan, Shengfeng Xu, Min Liu, Albino Bacolla, Ji Jing, Yian Du, John A. Tainer, Yin Shi, Zu Ye, Xiangdong Cheng   +23 more
wiley   +1 more source

An exploration of the role that expert knowledge plays in the assessment of undergraduate clinical competence: registered nurses' experiences [PDF]

, 2003
Penny Paliadelis, Mary Cruickshank
openalex   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Editorial: The evolving picture of Ca2+ leak from endoplasmic reticulum in health and diseases

Frontiers in Physiology, 2023
Adolfo Cavalié, Richard Zimmermann
doaj   +1 more source

Acquisition of clinical competence during postgraduate training in general practice [PDF]

, 2003
Anneke Kramer
openalex   +1 more source