Results 51 to 60 of about 200,357 (333)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

Alzheimer’s Research & Therapy, 2020
Background We evaluated Aβ misfolding in combination with Aβ42/40 ratio as a prognostic tool for future clinical progression to mild cognitive impairment (MCI) or dementia due to Alzheimer’s disease (AD) in individuals with subjective cognitive decline ...
Julia Stockmann, Inge M. W. Verberk, Nina Timmesfeld, Robin Denz, Brian Budde, Julia Lange-Leifhelm, Philip Scheltens, Wiesje M. van der Flier, Andreas Nabers, Charlotte E. Teunissen, Klaus Gerwert   +10 more
doaj   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

Teaching perspectives on the communication of difficult news of genetic conditions to medical students

American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 299-305, January 2023., 2023
Abstract Informing parents that their child has a diagnosis of Down syndrome (DS) is a common example of the delivery of unexpected or difficult news. Expectations and life planning will change, and if detected prenatally, discussions might include the option of pregnancy termination.
Ashley M. Vanasse, Tracey Weiler, Elizabeth A. Roth, Sharmila Upadhya, Helga V. Toriello, Ariel J. VanLeuven, John R. Norris, John C. Carey, Andrew K. Sobering   +8 more
wiley   +1 more source

Novice nurses’ professional competence: A qualitative content analysis

Journal of Education and Health Promotion
Background: Novice nurses comprise a significant number of health personnel who are working in health systems. The significance of acquiring professional competence by nurses entering the hospital will ensure results such as professionalizing and giving ...
Zahra Mehri, Ladan Zarshenas, Mahnaz Rakhshan, Zahra Khademian, Manoosh Mehrabi, Zahra Jamshidi   +5 more
doaj   +1 more source

Evaluation of clinical competence in nephrologists

Kidney International, 1988
A formal process for voluntary certification of nephrologists was introduced by the American Board of Internal Medicine (ABIM) in 1972. Five years later, the ABIM published guidelines for the training of nephrologists in the recognition that individuals could be held to the standard implied by certification only if their training in nephrology was of ...
John A. Benson, Richard J. Glassock, Jordan J. Cohen   +2 more
openaire   +3 more sources

Undergraduate medical education amid COVID-19: a qualitative analysis of enablers and barriers to acquiring competencies in distant learning using focus groups

Medical Education Online, 2021
Due to comprehensive social distancing measures related to the COVID-19 pandemic, medical faculties worldwide have made a virtue of necessity in resorting to online teaching.
Anika Reinhart, Bastian Malzkorn, Carsten Döing, Ines Beyer, Jana Jünger, Hans Martin Bosse   +5 more
doaj   +1 more source

A review of artificial intelligence in brachytherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Artificial intelligence (AI) has the potential to revolutionize brachytherapy's clinical workflow. This review comprehensively examines the application of AI, focusing on machine learning and deep learning, in various aspects of brachytherapy.
Jingchu Chen, Richard L. J. Qiu, Tonghe Wang, Shadab Momin, Xiaofeng Yang   +4 more
wiley   +1 more source

Methods for working with problem residents in medical physics residency education

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Medical physics residency training programs may occasionally encounter residents requiring additional intervention beyond normal training efforts. In the literature, these residents are referred to as “problem” residents. While the physician literature on the subject is valuable, this paper specifically focuses on dealing with a problem ...
Christopher J. Watchman, Dandan Zheng
wiley   +1 more source

Statistical inference methods for cumulative incidence function curves at a fixed point in time [PDF]

Communications in Statistics - Simulation and Computation, 2018, 2018
Competing risks data arise frequently in clinical trials. When the proportional subdistribution hazard assumption is violated or two cumulative incidence function (CIF) curves cross, rather than comparing the overall treatment effects, researchers may be interested in focusing on a comparison of clinical utility at some fixed time points.
arxiv   +1 more source