Results 61 to 70 of about 628,991 (311)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Predictors of New Graduate Nurses’ Organizational Commitment During a Nurse Residency Program [PDF]

, 2012
Retaining newly graduated nurses is critical for organizations because of the significant cost of turnover. Since commitment to an organization is associated with decreased turnover intent, understanding factors that influence new graduates ...
Bratt, Marilyn Meyer, Felzer, Holly M.
core   +1 more source

Professional development needs in nutrition and dietetics [PDF]

, 2019
Background. Continuing education has long played a role in the maintenance of professional competence of nutrition and dietetics professionals. Due to the lack of published continuing education research in nutrition over the last 15 years, very little is
James, Genevieve Elena
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

1,25-dihydroxyvitamin-D3 distinctly impacts the paracrine and cell-to-cell contact interactions between hPDL-MSCs and CD4+ T lymphocytes

Frontiers in Immunology
IntroductionHuman periodontal ligament-derived mesenchymal stromal cells (hPDL-MSCs) possess a strong ability to modulate the immune response, executed via cytokine-boosted paracrine and direct cell-to-cell contact mechanisms. This reciprocal interaction
Christian Behm, Oliwia Miłek, Katharina Schwarz, Xiaohui Rausch-Fan, Andreas Moritz, Oleh Andrukhov   +5 more
doaj   +1 more source

Assessment of Clinical Competence

Programmed Learning and Educational Technology, 1979
Abstract Current approaches to the examination of clinical competence at the undergraduate level are reviewed and differences in the approaches adopted in Australasia, Britain and North America are mentioned. The test methods used in these examinations are discussed critically and their separate strengths and weaknesses highlighted.
openaire   +1 more source

Conducting Successful Supervision: Novel Elements Towards an Integrative Approach [PDF]

, 2007
In recent years that has been an increasing interest in supervision within the UK's cognitive behaviour therapy (CBT) community. This is because the role of supervision has begun to be recognized in relation to the delivery of effective clinical services
Derek Milne, Ian Andrew James, Ivy, Marie - Blackburn, Peter Armstrong   +4 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Digital learning in nursing education: lessons from the COVID-19 lockdown

BMC Nursing
Background The COVID-19 pandemic necessitated a swift transition to e-learning, significantly impacting nursing education due to its reliance on practical, hands-on experiences and the critical role nurses play in healthcare.
Gro Gade Haanes, Etty Nilsen, Randi Mofossbakke, Marianne Wighus, Monika Ravik   +4 more
doaj   +1 more source

Applied sport psychology: Are we a profession? [PDF]

, 2015
Although the field of applied sport psychology has developed, it faces further challenges on its way towards gaining greater professional status. The following principal criteria of professionalism are proposed as a test of such status (Carr, 1999): (a)
Collins, D., Winter, S.,
core   +2 more sources