Results 51 to 60 of about 628,991 (311)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Modified 1-min sit-to-stand test for evaluating exercise capacity in pulmonary fibrosis

ERJ Open Research
Question The reference test for the functional evaluation of pulmonary fibrosis (PF) during exercise is the 6-min walk test (6MWT). However, the 6MWT involves temporal and spatial constraints that the 1-min sit-to-stand test (1-MSTST) does not have ...
Ingrid Berger, Sadek Mortada, Clémence Gachie, Hélène Beaussier, Emmanuelle Sacco, Gilles Chatellier, Audrey Fels, Marine Cachanado, Jean-Marc Naccache   +8 more
doaj   +1 more source

Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

Alzheimer’s Research & Therapy, 2020
Background We evaluated Aβ misfolding in combination with Aβ42/40 ratio as a prognostic tool for future clinical progression to mild cognitive impairment (MCI) or dementia due to Alzheimer’s disease (AD) in individuals with subjective cognitive decline ...
Julia Stockmann, Inge M. W. Verberk, Nina Timmesfeld, Robin Denz, Brian Budde, Julia Lange-Leifhelm, Philip Scheltens, Wiesje M. van der Flier, Andreas Nabers, Charlotte E. Teunissen, Klaus Gerwert   +10 more
doaj   +1 more source

Assessing Professionalism: A theoretical framework for defining clinical rotation assessment criteria [PDF]

, 2016
Although widely accepted as an important graduate competence, professionalism is a challenging outcome to define and assess. Clinical rotations provide an excellent opportunity to develop student professionalism through the use of experiential learning ...
Armitage-Chan E, Biggs J, Brainard AH, Braun V, Castellani B, Cruess R, Cruess RL, Cruess SR, Flin R, Freidson E, Ginsburg S, Hatton N, Hodges BD, Lane IF, Martimianakis MA, Monrouxe L, Rees CE, Wasserstein AG, Widick C, Wood J, Wynia MK   +20 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Boosting clinical performance: The impact of enhanced final year placements. [PDF]

, 2017
BACKGROUND: This study follows on from a study that investigated how to develop effective final year medical student assistantship placements, using multidisciplinary clinical teams in planning and delivery.
A. M. Reid, Cohen J., Cumming G., D. V. H. Williams, IBM., Illing J, M. Homer, Monrouxe L   +7 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The one minute mentor : a pilot study assessing medical students’ and residents’ professional behaviours through recordings of clinical preceptors’ immediate feedback [PDF]

, 2009
Introduction: The assessment of professional development and behaviour is an important issue in the training of medical students and physicians. Several methods have been developed for doing so.
Ellaway, Rachel, Evans, Rebecca, Nan Tie, Rod, Thistlethwaite, Jill, Topps, D.   +4 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Novice nurses’ professional competence: A qualitative content analysis

Journal of Education and Health Promotion
Background: Novice nurses comprise a significant number of health personnel who are working in health systems. The significance of acquiring professional competence by nurses entering the hospital will ensure results such as professionalizing and giving ...
Zahra Mehri, Ladan Zarshenas, Mahnaz Rakhshan, Zahra Khademian, Manoosh Mehrabi, Zahra Jamshidi   +5 more
doaj   +1 more source