Results 51 to 60 of about 6,428,705 (303)

Establishment of a competence office for patient involvement (PPI Office) at a German university hospital

Research Involvement and Engagement
Background In recent years, the involvement of patient representatives has become increasingly important in the planning, conduct, and communication of clinical trials.
Bettina C. Thomas, Friederike Dominick, Andrea Seidel-Glätzer, Gregor B. Ottawa, Steffen P. Luntz   +4 more
doaj   +1 more source

Correction to: Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

Alzheimer’s Research & Therapy, 2021
An amendment to this paper has been published and can be accessed via the original article.
Julia Stockmann, Inge M. W. Verberk, Nina Timmesfeld, Robin Denz, Brian Budde, Julia Lange-Leifhelm, Philip Scheltens, Wiesje M. van der Flier, Andreas Nabers, Charlotte E. Teunissen, Klaus Gerwert   +10 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Modified 1-min sit-to-stand test for evaluating exercise capacity in pulmonary fibrosis

ERJ Open Research
Question The reference test for the functional evaluation of pulmonary fibrosis (PF) during exercise is the 6-min walk test (6MWT). However, the 6MWT involves temporal and spatial constraints that the 1-min sit-to-stand test (1-MSTST) does not have ...
Ingrid Berger, Sadek Mortada, Clémence Gachie, Hélène Beaussier, Emmanuelle Sacco, Gilles Chatellier, Audrey Fels, Marine Cachanado, Jean-Marc Naccache   +8 more
doaj   +1 more source

Association of Excessive Sleepiness, Pathological Fatigue, Depression, and Anxiety With Different Severity Levels of Obstructive Sleep Apnea

Frontiers in Psychology, 2022
ObjectiveThe aim of this study was to investigate possible associations between obstructive sleep apnea and fatigue. This naturally led to considering the association between OSA and excessive sleepiness, depression, and anxiety.BackgroundOSA is a highly
Karin Elisabeth Sundt Mjelle, Sverre Lehmann, Sverre Lehmann, Sverre Lehmann, Ingvild West Saxvig, Ingvild West Saxvig, Shashi Gulati, Shashi Gulati, Bjørn Bjorvatn, Bjørn Bjorvatn, Bjørn Bjorvatn   +10 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Evaluation of clinical competence in nephrologists

Kidney International, 1988
A formal process for voluntary certification of nephrologists was introduced by the American Board of Internal Medicine (ABIM) in 1972. Five years later, the ABIM published guidelines for the training of nephrologists in the recognition that individuals could be held to the standard implied by certification only if their training in nephrology was of ...
Cohen, Jordan J., Glassock, Richard J., Benson, John A.   +2 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

No obvious effect on mortality from a patient choice reform expanding access to opioid disorder treatment – results from a natural experiment of policy change in Sweden

Substance Abuse Treatment, Prevention, and Policy, 2023
Background Opioid-related overdose deaths remain a common cause of death in many settings, and opioid maintenance treatment is evidence-based for the treatment of opioid use disorders.
Anders Håkansson, Sahar Janfada-Baloo, Jonas Berge   +2 more
doaj   +1 more source