375 Comparison of Electronic Clinical Decision Support for the Diagnosis of Suspected Pulmonary Embolism in Three Health Care Systems [PDF]
, 2018 Joseph Bledsoe +9 more
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Managing Patient Health Across Diverse Spaces: Using Activity Theory to Model Pervasive Decision Support [PDF]
, 2012 Clinical decision support (CDS) systems can offer health care providers and patient data that is intelligently filtered and presented in ways to enhance diagnosis and long-term health care management, both within and outside clinical spaces.
Boston-Clay, Crystal +4 more
core
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Towards the Development of the Clinical Decision Support System for the Identification of Respiration Diseases via Lung Sound Classification Using 1D-CNN [PDF]
S ALI +6 more
openalex +1 more source
OP0144 SLE-T2T – A DIGITAL TREAT-TO-TARGET CLINICAL DECISION SUPPORT SYSTEM FOR THE MANAGEMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS: DEVELOPMENT AND USABILITY EVALUATION [PDF]
, 2022 Agner Parra Sanchez +9 more
openalex +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source