Results 121 to 130 of about 10,615,218 (316)
The diagnosis of LAPSS and the clinical diagnosis.
, 2013 The diagnosis of LAPSS and the clinical diagnosis.
Yong Zhou (23772) +9 more
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Clinical Determinants and Prognostic Impact of Delayed Diagnosis in Wilson’s Disease
Background: Wilson’s disease (WD) is a rare hereditary disorder caused by pathological copper accumulation in multiple tissues. We aimed to assess the extent and determinants of diagnostic delay in WD adult patients treated at a Polish referral ...
Anna Członkowska +3 more
core +1 more source
Clinical misdiagnosis of Morton's Neuroma: a case of early rheumatoid arthritis
, 2003 A fit and apparently healthy male patient presents with symptoms and clinical signs consistent with a Morton's neuroma. Following excisional surgery, histopathology confirms the lesion as a rheumatoid nodule; this proves to be the presenting feature of ...
Robinson, C.J., Otter, S.J., Bowen, C.J.
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Can a computer expert system aid the process of clinical decision-making in podiatry? [PDF]
The aim of this research was to invetigate the clinical decision-making processes used in podiatry and hence to investigate if a computer expert system could be used to aid the process of clinical decision-making.
Curran, Mike
core
Novel Diagnostic approach for tuberculosis diagnosis [PDF]
, 2010 There is a clear need for a rapid, inexpensive point-of-care diagnostic test for tuberculosis (TB). The aim of this study was to analyze the performance of a novel rapid diagnostic test for TB, GeneXpert MTB/RIF, in symptomatic adults and to compare it ...
Milovic, Ana
core +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
MMP8 Promotes NETosis in Gestational Diabetes Mellitus
AntioxidantsBackground: Neutrophil extracellular traps (NETs) have been known to be involved in the gestational diabetes mellitus (GDM), but the underlying role remains poorly understood. Methods: We conducted an integrated analysis of bulk RNA-seq data, single-cell
Nan Li +8 more
doaj +1 more source