Results 101 to 110 of about 12,748 (196)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics. [PDF]

Nat Cardiovasc Res
Amancherla K, Oill AMT, Bledsoe X, Williams AL, Chow N, Smith AJ, Farrow MA, Zhao S, Sheng Q, Bearl DW, Perez AN, Hoffman RD, Menachem JN, Siddiqi HK, Brinkley DM, Mee ED, Hadad N, Agrawal V, Schmeckpepper J, Rali A, Tsai S, Farber-Eger E, Wells QS, Freedman JE, Tucker NR, Spraggins JM, Schlendorf KH, Gamazon ER, Banovich N, Shah RV.   +29 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Temporoparietalis Muscle: A Cadaveric Study of 60 Hemisides. [PDF]

Plast Reconstr Surg Glob Open
Yi KH, Wong IKJ, Park HJ, Rosellini I, Corrêa MC, Swift A.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Epigenetic clocks can differentiate between exogenous and endogenous skin ageing. [PDF]

Clin Epigenetics
Shore CJ, Simons RB, Del Caño LR, Xiong Z, Pardo LM, Eecen CMW, Nijsten T, Small KS, Vidaki A, Kayser M, Bell JT, Shen YJ, Gunn DA.   +12 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Diagnostic modalities in vascularized composite allotransplantation: from histopathology to multimodal strategies. [PDF]

Front Immunol
Crisler WJ, Klimitz FJ, Steuart SJ, Ko CJ, Clark RA, Pomahac B, Kauke-Navarro M.   +6 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Clinicopathological Characteristics of Acute Antibody-Mediated Rejection in Pediatric Liver Transplantation-A Single-Center Study. [PDF]

J Clin Med
Szymanska S, Piątosa B, Ciopiński M, Kijewski A, Kaliciński P, Markiewicz-Kijewska M.   +5 more
europepmc   +1 more source