Results 1 to 10 of about 31,682 (191)
PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species [PDF]
Advanced ScienceIron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is a key driver of ferroptosis in retinal pigment epithelial (RPE) cells, a process closely associated with age‐related macular degeneration (AMD).
Zhiyang Chen +19 more
doaj +2 more sources
Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease [PDF]
Molecular Therapy: Methods & Clinical DevelopmentAge-related macular degeneration (AMD) represents a major global health burden, with current estimates suggesting that up to 200 million people are affected globally. While effective treatments exist for the exudative form of the disease termed choroidal
Avril Reddy +7 more
doaj +2 more sources
Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion
PLoS ONE, 2022 Chediak–Higashi syndrome, caused by mutations in the Lysosome Trafficking Regulator (Lyst) gene, is a recessive hypopigmentation disorder characterized by albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of ...
Xiaojie Ji +8 more
doaj +3 more sources
Frontiers in Virology, 2022 Uveitis is a common manifestation of post-Ebola syndrome, associated with persistence of Ebola virus (EBOV; Zaire ebolavirus) inside the eye. The iris and retinal pigment epithelia are key components of the blood-ocular barriers, but have the capacity to
Shawn Todd +8 more
doaj +1 more source
Up-Regulation of ENO1 by HIF-1α in Retinal Pigment Epithelial Cells after Hypoxic Challenge Is Not Involved in the Regulation of VEGF Secretion. [PDF]
PLoS ONE, 2016 Alpha-enolase (ENO1), a major glycolytic enzyme, is reported to be over-expressed in various cancer tissues. It has been demonstrated to be regulated by the Hypoxia-inducible factor 1-α (HIF-1α), a crucial transcriptional factor implicated in tumor ...
Feihui Zheng +4 more
doaj +1 more source
Nature Communications, 2022 One common cause of vision loss after retinal detachment surgery is retinal scarring. Here the authors demonstrate that a bio-functional polymer can prevent retinal scarring by suppression of epithelial-mesenchymal transition and hyper-proliferation of ...
Bhav Harshad Parikh +27 more
doaj +1 more source
Bisretinoids of the Retina: Photo-Oxidation, Iron-Catalyzed Oxidation, and Disease Consequences
Antioxidants, 2021 The retina and, in particular, retinal pigment epithelial cells are unusual for being encumbered by exposure to visible light, while being oxygen-rich, and also amassing photoreactive molecules.
Hye Jin Kim +3 more
doaj +1 more source
Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization
Antioxidants, 2023 Age-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals in developed countries. Despite advances in our understanding of AMD, its pathophysiology remains poorly understood.
Jorge González-Zamora +8 more
doaj +1 more source
PLoS ONE, 2022 Chloroquine often causes serious eye and vision problems, which are mainly mediated by lysosomotropic alteration. In this study, we investigated whether the ginsenoside protopanaxadiol relieves chloroquine-induced retinopathy by restoring lysosomotropic ...
Haesung Lee +2 more
doaj +3 more sources
Microorganisms, 2022 Prevalence of dengue retinopathy varies across epidemics, with the disease linked to circulation of dengue virus serotype 1 (DENV-1). The retinal pigment epithelium has been implicated in the pathology.
Liam M. Ashander +8 more
doaj +1 more source