Results 1 to 10 of about 30,619 (236)

A model for de novo pigmentation of amelanotic retinal pigment epithelial cells. [PDF]

Acta Ophthalmol
Abstract Purpose Retinal Pigment Epithelial (RPE) cells perform critical functions in the visual cycle. Their melanin pigmentation, which is organized into specialized compartments – melanosomes, is highly critical for proper vision.
Gupta S, Lytvynchuk L, Ardan T, Studenovska H, Faura G, Eide L, Znaor L, Erceg S, Stieger K, Motlik J, Petrovski G.   +10 more
europepmc   +5 more sources

The effect of docetaxel on retinal pigment epithelial cells

Toxicology Reports, 2022
Docetaxel (DTX) is a highly effective anti-tumor drug frequently used in clinical practice. Previous reports indicated that complications after DTX therapy could be related to retinal pigment epithelial (RPE) cell dysfunction, although no direct reports ...
Jialin Li, Xiao Liu, Qiaohui Yang, Jian Huang, Wang Zhou, Zhirong Tan, Zhuo Li, Di Zhou   +7 more
doaj   +3 more sources

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species [PDF]

Advanced Science
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is a key driver of ferroptosis in retinal pigment epithelial (RPE) cells, a process closely associated with age‐related macular degeneration (AMD).
Zhiyang Chen, Xiaoman Zhu, Michael Mingze Lu, Qingjian Ou, Xueying Wang, Zhenzhen Zhao, Qi Shen, Qian Wang, Zhe Wang, Jing‐Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Xiaoliang Jin, Yanlong Bi, Lixia Lu, Guo‐Tong Xu, Haibin Tian   +19 more
doaj   +2 more sources

Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease [PDF]

Molecular Therapy: Methods & Clinical Development
Age-related macular degeneration (AMD) represents a major global health burden, with current estimates suggesting that up to 200 million people are affected globally. While effective treatments exist for the exudative form of the disease termed choroidal
Avril Reddy, Chris Greene, Yosuke Hashimoto, Anna-Sophia Kiang, Natalie Hudson, Peter Adamson, Tiago Santos-Ferreira, Matthew Campbell   +7 more
doaj   +2 more sources

Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells via injectable microfluidic-templated microgels for retinal regeneration [PDF]

Materials Today Bio
Retinal pigment epithelial (RPE) cells are specialized neural cells crucial for vision, while human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells hold great potential as a viable cell source for treating retinal degenerative ...
Ying Wei, Cong Ma, Chuanfeng An, Yujie Zhang, Haoyue Zhang, Qiyou Li, Li Kong, Huanan Wang, Xiang Ma   +8 more
doaj   +2 more sources

Effect of curcumin on aging retinal pigment epithelial cells

Drug Design, Development and Therapy, 2015
Wei Zhu,1,* Yan Wu,2,* Yi-Fang Meng,1 Jin-Yu Wang,1 Ming Xu,1 Jian-Jun Tao,1 Jiong Lu1 1Department of Ophthalmology, Changshu No 2 People’s Hospital, Changshu, 2Department of Ophthalmology, The First People’s Hospital of Kunshan Affiliated ...
Zhu W, Wu Y, Meng YF, Wang JY, Xu M, Tao JJ, Lu J   +6 more
doaj   +5 more sources

Human retinal pigment epithelial cells [PDF]

Cell Proliferation, 2021
Abstract'Human retinal pigment epithelial cells' is the first set of guidelines on human retinal pigment epithelial cells in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies technical requirements, test methods, inspection rules, instructions for usage, labelling requirements ...
Lei Wang, Jiani Cao, Yaojin Peng, Boqiang Fu, Zibing Jin, Yuntao Hu, Wei Wu, Andy peng Xiang, Shijun Hu, Junying Yu, Yu Zhang, Jun Wei, Yong Zhang, Qiyuan Li, Jiaxi Zhou, Peijun Zhai, Huanxin Zhu, Lingmin Liang, Aijin Ma, Glyn Stacey, Tongbiao Zhao, Jie Hao   +21 more
openaire   +2 more sources

Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion

PLoS ONE, 2022
Chediak–Higashi syndrome, caused by mutations in the Lysosome Trafficking Regulator (Lyst) gene, is a recessive hypopigmentation disorder characterized by albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of ...
Xiaojie Ji, Lihong Zhao, Ankita Umapathy, Bernard Fitzmaurice, Jieping Wang, David S. Williams, Bo Chang, Jürgen K. Naggert, Patsy M. Nishina   +8 more
doaj   +3 more sources

Retinal pigment epithelial cell proliferation [PDF]

Experimental Biology and Medicine, 2015
The human retinal pigment epithelium forms early in development and subsequently remains dormant, undergoing minimal proliferation throughout normal life. Retinal pigment epithelium proliferation, however, can be activated in disease states or by removing retinal pigment epithelial cells into culture.
Jeffrey, Stern, Sally, Temple
openaire   +2 more sources

Brief Research Report: Ebola Virus Differentially Infects Human Iris and Retinal Pigment Epithelial Cells

Frontiers in Virology, 2022
Uveitis is a common manifestation of post-Ebola syndrome, associated with persistence of Ebola virus (EBOV; Zaire ebolavirus) inside the eye. The iris and retinal pigment epithelia are key components of the blood-ocular barriers, but have the capacity to
Shawn Todd, Yuefang Ma, Liam M. Ashander, Binoy Appukuttan, Michael Z. Michael, Timothy A. Blenkinsop, Steven Yeh, Glenn A. Marsh, Justine R. Smith   +8 more
doaj   +1 more source