Results 31 to 40 of about 30,619 (236)

Multimodal imaging of the course of retinal changes in acute posterior multifocal placoid pigment epitheliopathy with bilateral retinal detachment: a case report

BMC Ophthalmology, 2022
Background To report a rare case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) with a combination of serous retinal detachment, papilledema, and retinal vasculitis.
Gang Su, Jia Meng, Hong Li, Shan-Jun Cai
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover

Nature Communications
Although mutations in human patatin-like phospholipase PNPLA6 are associated with hereditary retinal degenerative diseases, its mechanistic action in the retina is poorly understood.
Takashi Ono, Yoshitaka Taketomi, Takayoshi Higashi, Hiroyasu Sato, Chika Mochizuki-Ono, Yuki Nagasaki, Takashi Ueta, Takashi Miyai, Suzumi M. Tokuoka, Yoshiya Oda, Yasumasa Nishito, Tomio Ono, Choji Taya, Satoru Arata, Sumiko Watanabe, Tomoyoshi Soga, Tetsuya Hirabayashi, Makoto Aihara, Makoto Murakami   +18 more
doaj   +1 more source

Lipopolysaccharide enhances HSV-1 replication and inflammatory factor release in the ARPE-19 cells

Heliyon, 2022
Purpose: During acute retinal necrosis (ARN), retinal pigment epithelial (RPE) cells could be stimulated by both herpes simplex virus (HSV) and lipopolysaccharide (LPS).
Fang Duan, Weiting Zeng, Yafang Zhang, Dai Li, Kaili Wu   +4 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Retinal Pigment Epithelial Cells Release Inhibitors of Neovascularization

Ophthalmology, 1987
Human retinal pigment epithelial (RPE) cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells and human retinal microvessel endothelial cells in vitro.
B M, Glaser, P A, Campochiaro, J L, Davis, J A, Jerdan   +3 more
openaire   +2 more sources

Ocular immune privilege and retinal pigment epithelial cells

Journal of Leukocyte Biology, 2023
AbstractThe ocular tissue microenvironment is immune-privileged and uses multiple immunosuppressive mechanisms to prevent the induction of inflammation. The retinal pigment epithelium plays an essential role in ocular immune privilege. In addition to serving as a blood barrier separating the fenestrated choriocapillaris from the retina, the retinal ...
Yuxiang, Du, Bo, Yan
openaire   +2 more sources

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source

AA344 and AA345 antibodies recognize the microtubule network in human cells by immunofluorescence

Antibody Reports, 2019
The recombinant antibodies AA344 and AA345 detect the microtubule network by immunofluorescence in interphase and mitotic glutaraldehyde-fixed Retinal Pigment Epithelial cells (hTert-RPE1).
Amanda Guerreiro, Patrick Meraldi
doaj   +1 more source

Hamartomas of the Retina and Optic Disc

Türk Oftalmoloji Dergisi, 2022
Hamartomas are local malformation of cells that demonstrate abnormal proliferation in the area where they are normally present. Retinal and optic disc hamartomas include astrocytic hamartoma, congenital hypertrophy of the retinal pigment epithelium ...
Ibadulla Mirzayev, Ahmet Kaan Gündüz
doaj   +1 more source