Results 21 to 30 of about 34,005 (206)
Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization
Antioxidants, 2023 Age-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals in developed countries. Despite advances in our understanding of AMD, its pathophysiology remains poorly understood.
Jorge González-Zamora +8 more
doaj +1 more source
PLoS ONE, 2022 Chloroquine often causes serious eye and vision problems, which are mainly mediated by lysosomotropic alteration. In this study, we investigated whether the ginsenoside protopanaxadiol relieves chloroquine-induced retinopathy by restoring lysosomotropic ...
Haesung Lee +2 more
doaj +3 more sources
Generating retinal neurons by reprogramming retinal pigment epithelial cells [PDF]
Expert Opinion on Biological Therapy, 2010 Retinal degenerations cause blindness. One potential therapy is cell replacement. Because the human retina lacks regeneration capacity, much attention has been directed towards searching for cells that can differentiate into retinal neurons.We discuss the possibility of using transcription factor genes to channel retinal pigment epithelial (RPE) cells'
Shu-Zhen, Wang +3 more
openaire +2 more sources
Microorganisms, 2022 Prevalence of dengue retinopathy varies across epidemics, with the disease linked to circulation of dengue virus serotype 1 (DENV-1). The retinal pigment epithelium has been implicated in the pathology.
Liam M. Ashander +8 more
doaj +1 more source
Exocytosis by Retinal Pigment Epithelial Cells
Ophthalmic Research, 2009 We observed cultured retinal pigment epithelial cells as they responded to the introduction of latex particles. The cells showed phagocytosis of particles 1 h after administration of latex and were filled with particles after 24 h. After 7 days, exocytosis of latex from basal plasma membrane was documented.
M, Matsumura +4 more
openaire +2 more sources
Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]
, 2012 The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Johannes Burger +8 more
core +1 more source
Communications Biology, 2022 The in vivo pathogenesis of the blinding retinal degeneration choroideremia is visualized, which reveals enlarged and area-disrupted retinal pigment epithelial cells, providing evidence for polymegathism in choroideremia.
Nancy Aguilera +24 more
doaj +1 more source
Profound Re-Organization of Cell Surface Proteome in Equine Retinal Pigment Epithelial Cells in Response to In Vitro Culturing [PDF]
, 2012 The purpose of this study was to characterize the cell surface proteome of native compared to cultured equine retinal pigment epithelium (RPE) cells. The RPE plays an essential role in visual function and represents the outer blood-retinal barrier.
Kerstin N. Euler +25 more
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2019 Age-related macular degeneration (AMD) is a progressive retinal disorder characterized by imbalanced pro- and antiangiogenic signals. The aim of this study was to evaluate the effect of ex vivo cell-based gene therapy with stable expression of human ...
Maria Hernandez +18 more
doaj +1 more source
A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation
iScience, 2021 Summary: Retinal stem cells (RSCs) are rare pigmented cells found in the pigmented ciliary layer of the mammalian retina. Studies show that RSCs can replicate to maintain the stem cell pool and produce retinal progenitors that differentiate into all ...
Tahani W. Baakdhah +2 more
doaj +1 more source