Results 11 to 20 of about 34,005 (206)
Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease [PDF]
Molecular Therapy: Methods & Clinical DevelopmentAge-related macular degeneration (AMD) represents a major global health burden, with current estimates suggesting that up to 200 million people are affected globally. While effective treatments exist for the exudative form of the disease termed choroidal
Avril Reddy +7 more
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Immunological Molecular Responses of Human Retinal Pigment Epithelial Cells to Infection With Toxoplasma gondii [PDF]
Frontiers in Immunology, 2019 Ocular toxoplasmosis is the commonest clinical manifestation of infection with obligate intracellular parasite, Toxoplasma gondii. Active ocular toxoplasmosis is characterized by replication of T.
Shervi Lie +13 more
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International Journal of Nanomedicine, 2011 Cheng-Wei Chen1, Da-Wen Lu2, Ming-Kung Yeh3, Chia-Yang Shiau4, Chiao-Hsi Chiang1,5 1Graduate Institute of Life Sciences, 2Department of Ophthalmology, Tri-Service General Hospital, 3Institution of Preventive Medicine, 4Graduate Institute of Medical ...
Chen CW +4 more
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Human retinal pigment epithelial cells [PDF]
Cell Proliferation, 2021 Abstract'Human retinal pigment epithelial cells' is the first set of guidelines on human retinal pigment epithelial cells in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies technical requirements, test methods, inspection rules, instructions for usage, labelling requirements ...
Lei Wang +21 more
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Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion
PLoS ONE, 2022 Chediak–Higashi syndrome, caused by mutations in the Lysosome Trafficking Regulator (Lyst) gene, is a recessive hypopigmentation disorder characterized by albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of ...
Xiaojie Ji +8 more
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Retinal pigment epithelial cell proliferation [PDF]
Experimental Biology and Medicine, 2015 The human retinal pigment epithelium forms early in development and subsequently remains dormant, undergoing minimal proliferation throughout normal life. Retinal pigment epithelium proliferation, however, can be activated in disease states or by removing retinal pigment epithelial cells into culture.
Jeffrey, Stern, Sally, Temple
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Frontiers in Virology, 2022 Uveitis is a common manifestation of post-Ebola syndrome, associated with persistence of Ebola virus (EBOV; Zaire ebolavirus) inside the eye. The iris and retinal pigment epithelia are key components of the blood-ocular barriers, but have the capacity to
Shawn Todd +8 more
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Up-Regulation of ENO1 by HIF-1α in Retinal Pigment Epithelial Cells after Hypoxic Challenge Is Not Involved in the Regulation of VEGF Secretion. [PDF]
PLoS ONE, 2016 Alpha-enolase (ENO1), a major glycolytic enzyme, is reported to be over-expressed in various cancer tissues. It has been demonstrated to be regulated by the Hypoxia-inducible factor 1-α (HIF-1α), a crucial transcriptional factor implicated in tumor ...
Feihui Zheng +4 more
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Bisretinoids of the Retina: Photo-Oxidation, Iron-Catalyzed Oxidation, and Disease Consequences
Antioxidants, 2021 The retina and, in particular, retinal pigment epithelial cells are unusual for being encumbered by exposure to visible light, while being oxygen-rich, and also amassing photoreactive molecules.
Hye Jin Kim +3 more
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Nature Communications, 2022 One common cause of vision loss after retinal detachment surgery is retinal scarring. Here the authors demonstrate that a bio-functional polymer can prevent retinal scarring by suppression of epithelial-mesenchymal transition and hyper-proliferation of ...
Bhav Harshad Parikh +27 more
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