Results 11 to 20 of about 30,619 (236)
Up-Regulation of ENO1 by HIF-1α in Retinal Pigment Epithelial Cells after Hypoxic Challenge Is Not Involved in the Regulation of VEGF Secretion. [PDF]
PLoS ONE, 2016 Alpha-enolase (ENO1), a major glycolytic enzyme, is reported to be over-expressed in various cancer tissues. It has been demonstrated to be regulated by the Hypoxia-inducible factor 1-α (HIF-1α), a crucial transcriptional factor implicated in tumor ...
Feihui Zheng +4 more
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Nature Communications, 2022 One common cause of vision loss after retinal detachment surgery is retinal scarring. Here the authors demonstrate that a bio-functional polymer can prevent retinal scarring by suppression of epithelial-mesenchymal transition and hyper-proliferation of ...
Bhav Harshad Parikh +27 more
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Bisretinoids of the Retina: Photo-Oxidation, Iron-Catalyzed Oxidation, and Disease Consequences
Antioxidants, 2021 The retina and, in particular, retinal pigment epithelial cells are unusual for being encumbered by exposure to visible light, while being oxygen-rich, and also amassing photoreactive molecules.
Hye Jin Kim +3 more
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Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization
Antioxidants, 2023 Age-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals in developed countries. Despite advances in our understanding of AMD, its pathophysiology remains poorly understood.
Jorge González-Zamora +8 more
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PLoS ONE, 2022 Chloroquine often causes serious eye and vision problems, which are mainly mediated by lysosomotropic alteration. In this study, we investigated whether the ginsenoside protopanaxadiol relieves chloroquine-induced retinopathy by restoring lysosomotropic ...
Haesung Lee +2 more
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Microorganisms, 2022 Prevalence of dengue retinopathy varies across epidemics, with the disease linked to circulation of dengue virus serotype 1 (DENV-1). The retinal pigment epithelium has been implicated in the pathology.
Liam M. Ashander +8 more
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Exocytosis by Retinal Pigment Epithelial Cells
Ophthalmic Research, 2009 We observed cultured retinal pigment epithelial cells as they responded to the introduction of latex particles. The cells showed phagocytosis of particles 1 h after administration of latex and were filled with particles after 24 h. After 7 days, exocytosis of latex from basal plasma membrane was documented.
M, Matsumura +4 more
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Communications Biology, 2022 The in vivo pathogenesis of the blinding retinal degeneration choroideremia is visualized, which reveals enlarged and area-disrupted retinal pigment epithelial cells, providing evidence for polymegathism in choroideremia.
Nancy Aguilera +24 more
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Molecular Therapy: Methods & Clinical Development, 2019 Age-related macular degeneration (AMD) is a progressive retinal disorder characterized by imbalanced pro- and antiangiogenic signals. The aim of this study was to evaluate the effect of ex vivo cell-based gene therapy with stable expression of human ...
Maria Hernandez +18 more
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Generating retinal neurons by reprogramming retinal pigment epithelial cells [PDF]
Expert Opinion on Biological Therapy, 2010 Retinal degenerations cause blindness. One potential therapy is cell replacement. Because the human retina lacks regeneration capacity, much attention has been directed towards searching for cells that can differentiate into retinal neurons.We discuss the possibility of using transcription factor genes to channel retinal pigment epithelial (RPE) cells'
Shu-Zhen, Wang +3 more
openaire +2 more sources