Results 91 to 100 of about 8,630,835 (311)

Clinical efficacy of antibiotic-loaded bone cement and negative pressure wound therapy in multidrug-resistant organisms diabetic foot ulcers: a retrospective analysis

Frontiers in Cellular and Infection Microbiology
ObjectiveThe purpose of this study was to investigate the clinical efficacy of antibiotic-loaded bone cement (ALBC) combined with Negative pressure wound therapy (NPWT) aspiration technique in the treatment of multidrug-resistant diabetic foot ulcers ...
Huihui Guo, Zhenqiang Xue, Siwei Mei, Tengfei Li, Haiyang Yu, Tao Ning, Yongbin Fu   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Superior effect of adalimumab versus secukinumab on ultrasound-confirmed synovitis in psoriatic arthritis: comprehensive evidence from musculoskeletal ultrasound and clinical assessments

Journal of Dermatological Treatment
Background and objectives: Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disorder affecting 30% of psoriatic patients. Effective treatment, especially with biologics like IL-17 and TNF inhibitors, is vital for improving patient ...
Yiyi Wang, Yue Xiao, Lingyan Zhang, Furong Li, Hongxiang Hu, Xiya Peng, Jingya Gao, Min Yang, Wei Yan, Li Qiu, Wei Li   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Exploring lifelong learning outcomes among adult learners via goal orientation and information literacy self-efficacy [PDF]

, 2019
This study intends to explore the relationship between goal orientation, information literacy self-efficacy and lifelong learning outcomes of the adult learners.
Kowang, Tan Owee, Adriana Mohd Rizal, Rizal, A. M., Kowang, T. O., Goh Chin Fei, Ping, Lim Lee, Hee, O. C., Ong Choon Hee, Tan Owee Kowang, Fei, Goh Chin, Rizal, Adriana Mohd, Ping, L. L., Hee, Ong Choon, Lim Lee Ping, Fei, G. C.   +14 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Defining Clinical Malaria: The Specificity and Incidence of Endpoints from Active and Passive Surveillance of Children in Rural Kenya. [PDF]

, 2010
Febrile malaria is the most common clinical manifestation of P. falciparum infection, and is often the primary endpoint in clinical trials and epidemiological studies.
Olotu Ally, Bejon, P., Bejon, P, Fegan, G., Fegan, Gregory, Edna Ogada, Williams, TN, Borrmann Steffen, Wambua, J., Evasius Bauni, Ogada, E., Bejon, Philip, Borrmann, S, Marsh Kevin, Sasi, P, Fegan, G, Olotu, Ally, Juliana Wambua, Bauni, E, Fegan Gregory, Ogada Edna, Wambua, Juliana, Marsh, K., Sasi Philip, Ogada, E, Gregory Fegan, Sasi, P., Thomas N. Williams, Kevin Marsh, Thomas N Williams, Greg Fegan, Philip Sasi, Bauni, Evasius, Wambua, J, Sasi, Philip, Philip Bejon, Marsh, K, Wambua Juliana, Borrmann, S., Bauni Evasius, Bauni, E., Bejon Philip, Williams, Thomas N, Ogada, Edna, Borrmann, Steffen, Ally Olotu, Williams, Thomas, Marsh, Kevin, Olotu, A, Steffen Borrmann, Olotu, A., Williams, T.N., Williams Thomas N.   +52 more
core   +1 more source

It is not the best option to perform transurethral enucleation of the prostate immediately after biopsy in patients with histological inflammation

Frontiers in Surgery
ObjectiveThis study seeks to investigate the impact of histopathological evidence of histological prostatic inflammation (PI) on the surgical outcomes of patients with benign prostatic hyperplasia (BPH) undergoing transurethral bipolar enucleation of the
Tengfei Gu, Jie Li, Ting Chen, Yongtao Pan, Jing Sha   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source