Results 71 to 80 of about 8,630,835 (311)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children. [PDF]

, 2008
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.
Pinoges Loretxu, Balkan, S, Grant Dorsey, Pinoges, Loretxu, Hasifa Burkirwa, Olliaro, P, Pedro Pablo Palma Urruta, Checchi, Francesco, Ingrid van den Broek, Dorsey Grant, Urruta, P P P, Walter R Taylor, Michel van Herp, Ashley Elizabeth A, Dorsey, G, van Herp Michel, Turyakira, Eleanor, Guthmann, Jean-Paul, Ashley, Elizabeth A, Zongo Issaka, Taylor Walter R, van Herp, M, Francesco Checchi, Issaka Zongo, Turyakira, E, Zongo, I, Taylor, W R J, Balkan Suna, Dorsey, Grant, van den Broek Ingrid, van Herp, Michel, Ashley, E A, van den Broek, Ingrid, Taylor, Walter R, Urruta, Pedro Pablo Palma, Elizabeth A Ashley, Eleanor Turyakira, Olliaro Piero, Pinoges, L, Jean-Paul Guthmann, Guthmann, J P, Guthmann Jean-Paul, van den Broek, I, Piero Olliaro, Zongo, Issaka, Checchi Francesco, Bukirwa, H, Checchi, F, Loretxu Pinoges, Bukirwa, Hasifa, Turyakira Eleanor, Suna Balkan, Bukirwa Hasifa, Urruta Pedro, Balkan, Suna, Olliaro, Piero   +55 more
core   +1 more source

FMT reduces systemic inflammatory response in severe acute pancreatitis by increasing the abundance of intestinal Bifidobacteria and fecal bacteria

Biomolecules & Biomedicine
Severe acute pancreatitis (SAP) is one of the leading causes of hospital admissions for gastrointestinal diseases, with a rising incidence worldwide. Intestinal microbiota dysbiosis caused by SAP exacerbates systemic inflammatory response syndrome and ...
Yanning Mao, Yandong Huang, Weiwei Zhang, Huiping Liang, Fengming Liu, Qi Luo, Chunqin Xu, Yi Qin, Jiawen Liu, Shaobo Tang, Huaying Liu, Xiaolong Ge   +11 more
doaj   +1 more source

Clinical efficacy of the ketogenic diet

Epilepsy Research, 1999
The ketogenic diet is an effective alternative therapy used to control intractable seizures. It was originally described in 1921 as a way to duplicate and prolong the beneficial effects that fasting appeared to have on seizure control. It involves consuming a calorie-restricted diet in which the fat:carbohydrate + protein ratio ranges from 2:1 to 5:1 ...
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: Results of the MAP study [PDF]

, 2000
In a randomized clinical trial with an observation period of 2.5 years, the differential efficacy of lithium versus carbamazepine was compared in 171 bipolar patients (DSM-IV).
Waldemar Greil, Nikolaus Kleindienst, Greil, Waldemar, Kleindienst, Nikolaus   +3 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Efficacy and safety of the long-term oral administration of carprofen in the treatment of osteoarthritis in dogs [PDF]

, 2007
The aim of this study conducted in France was to confirm the efficacy and safety of the oral administration of carprofen (Rimadyl®) at 4 mg/kg once a day during four months in the treatment of clinically chronic osteoarthritis in dogs.
Autefage, André, Gosselin, Jacques
core   +1 more source

Comparison of intravitreal anti-VEGF agents and oral carbonic anhydrase inhibitors in the treatment of cystoid macular edema secondary to retinitis pigmentosa

Frontiers in Pharmacology
PurposeTo compare the efficacy of intravitreal antivascular endothelial growth factor (anti-VEGF) agents with oral carbonic anhydrase inhibitors (CAIs) in treating cystoid macular edema (CME) secondary to retinitis pigmentosa (RP).MethodsThis ...
Jia Liang, Xueping Wu, Lu Chen, Lujia Feng, Xiangqing Hei, Yingying Diao, Yuke Ji, Huiyan Zheng, Zhenhua Zou, Dong Fang, Shaochong Zhang   +10 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source