Results 81 to 90 of about 8,630,835 (311)

Meta-analysis of the Clinical Efficacy and Safety of Treating Amyotrophic Lateral Sclerosis Based on the Theory of Deficient Qi Induced Stagnation

Guoji laonian yixue zazhi
Objective To systematically evaluate the efficacy and safety of treating amyotrophic lateral sclerosis(ALS) based on the theory of “Deficient Qi Induced Stagnation”.
Xu Mengfang, Xu Tianjiao, Zhang Muzhao, Han Xiao, Wu Linlu, Chen Tianzhu, Ma Renzhao, Zou Yihuai   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The efficacy and prognosis analysis of short-term spinal cord stimulation in the treatment of zoster-associated pain: a retrospective study

Frontiers in Neurology
BackgroundZoster-associated pain (ZAP) is the most common and intractable complication in the clinical setting when patients with herpes zoster (HZ) seek medical treatment.
Xiang Wang, Yimin Gao, Jing Yu, Wenqu Yang, Wenjing Zhang, Jianzhong Huo   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Efficacy Evaluation of a Multifunctional Cosmetic Formulation: The Benefits of a Combination of Active Antioxidant Substances

Molecules, 2014
This study presents the association of active antioxidants substances in a multifunctional cosmetic formulation with established efficacy against signs of aging.
Mirela D. Gianeti, Patrícia M. B. G. Maia Campos   +1 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: the role of Médecins Sans Frontières. [PDF]

, 2008
Jean-Paul Guthmann and colleagues describe the output of MSF's work in antimalarial efficacy assessment during the last ...
Comte, Eric, Legros, Dominique, Francesco Checchi, Guthmann, JP, Balkan, S, Philippe J Guerin, Balkan Suna, Kindermans Jean-Marie, Legros, D, van den Broek Ingrid, Guerin Philippe J, van Herp, Michel, van den Broek, Ingrid, Checchi, Francesco, Ingrid van den Broek, Oscar Bernal, Guerin, Philippe J, Jean-Marie Kindermans, Dominique Legros, Jean-Paul Guthmann, Guerin, PJ, Comte Eric, Kindermans, JM, Michel van Herp, Guthmann Jean-Paul, Venis Sarah, van den Broek, I, Sarah Venis, Kindermans, Jean-Marie, van Herp Michel, Checchi Francesco, Comte, E, Checchi, F, Bernal, O, Guthmann, Jean-Paul, Legros Dominique, Eric Comte, Guerin, Philippe, Venis, Sarah, Suna Balkan, Venis, S, Bernal Oscar, Balkan, Suna, van Herp, M, Bernal, Oscar   +44 more
core   +1 more source

Clinical efficacy of photodynamic therapy

Obstetrics & Gynecology Science, 2016
The management of cervical intraepithelial neoplasia (CIN) and early invasive cancer of the uterine cervix is very difficult to approach, especially in case of young woman who wants to preserve her fertility. Conization of the cervix may have various kinds of disadvantage.
Ye-Kyu Park, Choong-Hak Park
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source