Results 61 to 70 of about 8,630,835 (311)

Early clinical development of targeted anticancer agents [PDF]

, 2017
Van Brummelen studied the safety and preliminary signs of efficacy of several novel targeted anticancer agents in phase I trials. In her thesis, she reports the results of trials with the immunotherapies pembrolizumab and cergutuzumab-amunaleukin, and ...
van Brummelen, E.M.J., Pharmacoepidemiology and Clinical Pharmacology, Sub Clinical Pharmacology   +2 more
core  

Clinical Observation of Apatinib in Treatment of Refractory Advanced Breast Cancer

Zhongliu Fangzhi Yanjiu, 2020
Objective To evaluate the clinical efficacy and safety of apatinib in the treatment of advanced breast cancer(ABC) patients refractory to multiline treatments.
WANG Jing, JIA Jinghao, LIU Jingjing, CUI Zhichao, XIONG Wei, WANG Xiaohong   +5 more
doaj   +1 more source

Efficacy and Safety of Tildrakizumab in Older Patients: Pooled Analyses of Two Randomized Phase III Clinical Trials (reSURFACE 1 and reSURFACE 2) Through 244 Weeks

Acta Dermato-Venereologica, 2023
The evidence on treating older patients with psoriasis with modern biologics is scarce. This study compared the efficacy and safety of tildrakizumab among younger and older patients with psoriasis (
Elke L. M. ter Haar, Juul M. P. A. van den Reek, Kristian Gaarn Du Jardin, Almudena Barbero-Castillo, Elke M. G. J. de Jong, Satish F. K. Lubeek   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs. [PDF]

, 2007
The proliferation of antimalarial drug trials in the last ten years provides the opportunity to launch a concerted global surveillance effort to monitor antimalarial drug efficacy. The diversity of clinical study designs and analytical methods undermines
Laufer, M K, Sibley, C H, Sibley, CH, Stepniewska, Barnes, K I, Guerin, P J, Philippe J Guerin, Ringwald, P, Grant Dorsey, Olliaro, P., Naidoo, I, J Kevin Baird, Stepniewska, K., d'Alessandro, U, Olliaro, P, Miriam K Laufer, Ashley, EA, Guerin, Philippe J, d\u27Alessandro, Umberto, Guerin, Philippe J., Laufer, M. K., François Nosten, D'Alessandro, U., Plowe, CV, Price, R N, Pascal Ringwald, Ringwald, Pascal, Barnes, Karen, Dorsey, G, d'Alessandro, Umberto, Barnes, K. I., Baird, J. Kevin, Inbarani Naidoo, Nicholas J White, Laufer, MK, Ashley, Elizabeth A, Stepniewska, K, Guerin, Philippe, Sibley, C. H., Naidoo, I., Christopher V Plowe, Ashley, E. A., Baird, John, Baird, J K, White, Nicholas, Nosten, François, Sibley, Carol H, Ashley, Elizabeth A., White, Nicholas J., Nosten, F., Barnes, KI, White, N. J., Price, Ric, Dorsey, Grant, Plowe, C V, Ashley, E A, Plowe, Christopher, Carol H Sibley, Baird, K., Barnes, Karen I., Baird, JK, White, Nicholas J, Laufer, Miriam K, Umberto d'Alessandro, Elizabeth A Ashley, Plowe, Christopher V., Nosten, F, White, N J, Guerin, PJ, Karen I Barnes, Guerin, P. J., Baird, J Kevin, Piero Olliaro, Plowe, C. V., Barnes, Karen I, Price, R. N., Sibley, Carol H., Dorsey, G., Price, Ric N., Plowe, Christopher V, Ringwald, P., Sibley, Carol, Laufer, Miriam K., Price, RN, Naidoo, Inbarani, Stepniewska, Kasia, Ashley, Elizabeth, Price, Ric N, Ric N Price, Kasia Stepniewska, White, NJ, Laufer, Miriam, Olliaro, Piero   +92 more
core   +1 more source

Clinical efficacy and effect on neurotransmitter levels of Shaoma Zhijing granules in children with tic disorders

Frontiers in Pediatrics
ObjectiveTo investigate the clinical efficacy of Shaoma Zhijing Granules in treating pediatric tic disorders and its impact on plasma neurotransmitter levels.MethodsEighty pediatric patients with tic disorders were randomly divided into the Shaoma ...
Yanping Wang, Miao Jing, Ying Hua, Lin Zhang, Jianbiao Wang, Xiaochun Fan   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Enhancing survival outcomes in unresectable hepatocellular carcinoma: a prospective cohort study on the effects of Huaier granules with targeted therapy plus immunotherapy

Frontiers in Pharmacology
ObjectiveThis study evaluated the clinical efficacy of Huaier granules combined with targeted therapy plus immunotherapy in patients with unresectable hepatocellular carcinoma (HCC) who had not undergone systemic treatment.MethodsPatients with ...
Hui Li, Hongliang Zhang, Wenting He
doaj   +1 more source

The Clinical Efficacy and Safety of Simvastatin in the Management of Portal Hypertension in Cirrhotic Patients: A Systematic Review

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020
Background: Variceal bleeding is a serious complication of portal hypertension in liver cirrhosis. Current guidelines recommend non-selective beta blockers (NSBBs) and endoscopic variceal ligation for primary prophylaxis of variceal bleeding.
Raksheeth Agarwal, Matthew Billy, Oliver Emmanuel Yausep, Radhian Amandito, Vito Filbert Jayalie, Rino Alvani Gani   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source