Results 41 to 50 of about 8,630,835 (311)

Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. [PDF]

, 2008
BACKGROUND: New antimalarial regimens, including artemisinin-based combination therapies (ACTs), have been adopted widely as first-line treatment for uncomplicated malaria.
Njama-Meya Denise, Staedke Sarah G, Catherine Maiteki-Sebuguzi, Sarah G Staedke, Denise Njama-Meya, Moses R Kamya, Kristin Banek, Maiteki-Sebuguzi Catherine, Grant Dorsey, Yeka Adoke, Jagannathan, Prasanna, Dorsey, Grant, Talisuna, Ambrose O, Arthur Mpimbaza, Dorsey Grant, Ambrose O Talisuna, Rosenthal Philip J, Hasifa Bukirwa, Jagannathan Prasanna, Maiteki-Sebuguzi, Catherine, Rosenthal, Philip J, Tamara D Clark, Clark Tamara D, Yeka, Adoke, Banek, Kristin, Nzarubara Bridget, Staedke, Sarah G, Prasanna Jagannathan, Banek Kristin, Mpimbaza Arthur, Bukirwa, Hasifa, Nzarubara, Bridget, Philip J Rosenthal, Njama-Meya, Denise, Clark, Tamara D, Adoke Yeka, Mpimbaza, Arthur, Kamya Moses R, Bridget Nzarubara, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Talisuna Ambrose O, Fred Wabwire-Mangen, Wabwire-Mangen, Fred   +44 more
core   +1 more source

Clinical efficacy analysis of paxlovid in children with hematological diseases infected with the omicron SARS-CoV-2 new variant

Frontiers in Pediatrics, 2023
ObjectiveTo summarize the clinical characteristics of children with hematological malignancies co-infected with novel coronavirus and explore the safety and effectiveness of Paxlovid treatment.MethodsFrom December 10, 2022, to January 20, 2023, the ...
Yixian Li, Yong Liu, Luping Wen, Hui Chen, Wenqing Wang, Mengyao Tian, Yucai Cheng, Hongman Xue, Chun Chen   +8 more
doaj   +1 more source

Clinical endpoints for efficacy studies

Vaccine, 2019
Well-established, validated and clinically meaningful primary and secondary endpoints are critical in advancing vaccines through proof of principal studies, licensure and pre-qualification. To that end, the field of vaccine development for Shigella, enterotoxigenic Escherichia coli (ETEC) as well as other enteric pathogens would benefit greatly from a ...
Chad K, Porter, Ramiro L, Gutierrez, Karen L, Kotloff   +2 more
openaire   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial [PDF]

, 2016
Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or clinical ...
Puchkov, Maxim, Maxim Puchkov, Jennifer Keiser, Jörg Huwyler, Coulibaly, Jean T., Beatrice Barda (717878), Maxim Puchkov (3123930), Jean T Coulibaly, Jan Hattendorf (113923), Jörg Huwyler (166572), Beatrice Barda, Jean T. Coulibaly (108845), Huwyler, Jörg, Hattendorf, Jan, Keiser, Jennifer, Jennifer Keiser (39606), Barda, Beatrice, Jan Hattendorf   +17 more
core   +2 more sources

A Pilot Study of A2NTX, a Novel Low-Molecular-Weight Neurotoxin Derived from Subtype A2 for Post-Stroke Lower Limb Spasticity: Comparison with OnabotulinumtoxinA

Toxins, 2022
All the currently used type A botulinum neurotoxins for clinical uses are of subtype A1. We compared the efficacy and safety for the first time head-to-head between a novel botulinum toxin A2NTX prepared from subtype A2 and onabotulinumtoxinA (BOTOX ...
Ryuji Kaji, Ai Miyashiro, Nori Sato, Taiki Furumoto, Toshiaki Takeuchi, Ryosuke Miyamoto, Tomoko Kohda, Yuishin Izumi, Shunji Kozaki   +8 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Person-centred therapy with a client experiencing social anxiety difficulties : a hermeneutic single case efficacy design [PDF]

, 2011
Social anxiety is a chronic, debilitating psychological condition. Hermeneutic Single Case Efficacy Design (HSCED) is a legalistic mixed-method case study method for evaluating therapy efficacy in single cases. Using a case of Person-Centred Therapy (PCT)
Stephen, Susan, Macleod, Rachel, Elliott, Robert   +2 more
core   +4 more sources

Efficacy of modified kidner procedure combined with subtalar arthroereisis treating adolescent type 2 painful accessory navicular with flexible flatfoot

Frontiers in Pediatrics, 2023
PurposeTo investigate the clinical efficacy of modified kidner procedure combined with subtalar arthroereisis in the treatment of adolescent type II painful accessory navicular with flexible flatfoot.MethodsFrom January 2018 to January 2022, 25 ...
Ke Fang, Ting Bi, Ao Hong, Xin Li, Haoli Gong, Bo Li, Fanling Li, Jie Wen, Jie Wen, Sheng Xiao   +9 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source