Results 21 to 30 of about 8,630,835 (311)

The time-course of protection of the RTS,S vaccine against malaria infections and clinical disease [PDF]

, 2015
Recent publications have reported follow-up of the RTS,S/AS01 malaria vaccine candidate Phase III trials at 11 African sites for 32 months (or longer).
Peter Pemberton-Ross, Melissa A. Penny, Smith, Thomas A., Thomas A. Smith, Pemberton-Ross, Peter, Penny, Melissa A.   +5 more
core   +1 more source

Effect of cement distribution type on clinical outcome after percutaneous vertebroplasty for osteoporotic vertebral compression fractures in the aging population

Frontiers in Surgery, 2022
ObjectiveThe study aimed to investigate the effect of the type of bone cement distribution on clinical outcomes following percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCF) in the elderly.MethodsRetrospective ...
Chengqiang Zhou, Chengqiang Zhou, Yifeng Liao, Yifeng Liao, Shaolong Huang, Shaolong Huang, Hua Li, Ziqiang Zhu, Li Zheng, Bin Wang, Yunqing Wang   +10 more
doaj   +1 more source

Tractography activation patterns in dorsolateral prefrontal cortex suggest better clinical responses in OCD DBS

Frontiers in Neuroscience, 2016
Background: Medication resistant obsessive-compulsive disorder (OCD) patients can be successfully treated with Deep Brain Stimulation (DBS) which targets the anterior limb of the internal capsule (ALIC) and the nucleus accumbens (NA).
Christian J. Hartmann, Christian J. Hartmann, J. Luis Lujan, J. Luis Lujan, Ashutosh eChaturvedi, Wayne K. Goodman, Michael S. Okun, Cameron C. McIntyre, Ihtsham U. Haq   +8 more
doaj   +1 more source

Efficacy and Safety of Infliximab in Intestinal Behçet’s Disease: A Multicenter, Phase 3 Study (BEGIN)

Gut and Liver, 2023
Background/Aims: To date, there is no prospective study that specifically investigated the efficacy of infliximab in intestinal Behçet’s disease (BD). This study evaluated the efficacy of infliximab in patients with moderate-to-severe active intestinal ...
Jae Hee Cheon, Hyun-Soo Kim, Dong Soo Han, Sung Kook Kim, Sung Jae Shin, Joo Sung Kim, Byong Duk Ye, Geun Am Song, YoungJa Lee, Youngdoe Kim, Yoosun Lee, Won Ho Kim, BEGIN Study Group   +12 more
doaj   +1 more source

Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials. [PDF]

, 2010
BACKGROUND: Phase III trials of the malaria vaccine, RTS, S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias estimates of vaccine efficacy ...
Michael T White, Jamie T Griffin, Azra C Ghani, Drakeley, Chris J, Ghani Azra C, Ghani, Azra C, Griffin, Jamie T, Drakeley Chris J, White, Michael T, White Michael T, Griffin Jamie T, Chris J Drakeley   +11 more
core   +1 more source

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]

, 2012
Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
Berger Michael, Dittmann, Sandra, Riedel Michael, Sophia, Frangou, Emanuel Severus, Bauer Michael, Severus, Emanuel, Pfennig Andrea, Florian Seemüller, Sophia Frangou, Michael, Bauer, Michael Bauer, Michael Riedel, Berger, Michael, Michael, Obermeier, Andrea, Pfennig, Michael Obermeier, Obermeier Michael, Seemüller Florian, Andrea Pfennig, Michael Berger, Hans-Jürgen, Möller, Dittmann Sandra, Michael, Riedel, Severus Emanuel, Frangou Sophia, Seemüller, Florian, Möller Hans-Jürgen, Sandra Dittmann, Hans-Jürgen Möller   +29 more
core   +2 more sources

The efficacy-effectiveness distinction in trials of alcohol brief intervention. [PDF]

, 2014
Three recent sets of null findings from trials of alcohol brief intervention (BI) have been disappointing to those who wish to see a reduction in alcohol-related harm through the widespread dissemination of BI.
Nick Heather, Heather, Nick
core   +1 more source

High-Dose Nebulized Colistin Methanesulfonate and the Role in Hospital-Acquired Pneumonia Caused by Gram-Negative Bacteria with Difficult-to-Treat Resistance: A Review

Microorganisms, 2023
Hospital-acquired pneumonia, including ventilator-associated pneumonia (VAP) due to difficult-to-treat-resistant (DTR) Gram-negative bacteria, contributes significantly to morbidity and mortality in ICUs.
Ilias Karaiskos, Aikaterini Gkoufa, Elena Polyzou, Georgios Schinas, Zoe Athanassa, Karolina Akinosoglou   +5 more
doaj   +1 more source

Systematic review and analysis of evidences on clinical efficacy and cost-effectiveness of biological drugs for the treatment of Ankylosing Spondylitis [PDF]

, 2013
Technology: Infliximab and comparator biological such as adalimumab, etanercept, golimumab. Conditions: Ankylosing spondylitis (AS) Issue: Infliximab is registered to be used in patients with AS.
Péntek, Márta
core   +1 more source

Clinical Efficacy and Safety of Propranolol in the Prevention and Treatment of Retinopathy of Prematurity: A Meta-Analysis of Randomized Controlled Trials

Frontiers in Pediatrics, 2021
Objective: To perform a meta-analysis of randomized controlled trials verifying clinical efficacy and safety of propranolol in pre-term newborns with retinopathy of prematurity (ROP).Methods: We searched the literature databases (Pubmed, Embase, The ...
Haibo B. Kong, Guoyuan Y. Zheng, Baomei M. He, Ying Zhang, Qin Zhou   +4 more
doaj   +1 more source