Results 11 to 20 of about 8,630,835 (311)

The clinical analgesic efficacy of buprenorphine [PDF]

Journal of Clinical Pharmacy and Therapeutics, 2014
Based on in vitro assays and select animal models, buprenorphine is commonly called a 'partial agonist'. An implication is that it should produce less analgesic effect in humans than so-called 'full agonists' such as morphine or fentanyl. However, buprenorphine has a multimechanistic pharmacology, and thus partial agonism at a specific receptor is not ...
R B, Raffa, M, Haidery, H-M, Huang, K, Kalladeen, D E, Lockstein, H, Ono, M J, Shope, O A, Sowunmi, J K, Tran, J V, Pergolizzi   +9 more
openaire   +2 more sources

Hermeneutic single-case efficacy design [PDF]

, 2002
In this article, I outline hermeneutic single-case efficacy design (HSCED), an interpretive approach to evaluating treatment causality in single therapy cases.
R. Elliott, Elliott, Robert
core   +4 more sources

Unlocking potential: clinical benefits of enlarging the nail bed explored through continuous W-shaped incisions

Journal of Dermatological Treatment, 2023
Purpose Nail bed atrophy, a common condition for which conservative treatments have limited efficacy, continues to present challenges in determining the optimal surgical intervention.
Yaxin Xue, Zijing Du, Chao Du, Jiajun Fan, Jia Xu, Xin Li, Hao Lv, Yi Cao, Dong Han   +8 more
doaj   +1 more source

Efficacy and safety of the RTS,S/AS01 malaria vaccine during 18 months after vaccination : a phase 3 randomized, controlled trial in children and young infants at 11 African sites [PDF]

, 2014
A malaria vaccine could be an important addition to current control strategies. We report the safety and vaccine efficacy (VE) of the RTS,S/AS01 vaccine during 18 mo following vaccination at 11 African sites with varying malaria transmission.; 6,537 ...
RTS, S. Clinical Trials Partnership, RTS,S Clinical Trials Partnership, The RTS,S Clinical Trials Partnership (2014) (614272)   +2 more
core   +1 more source

The Efficacy of Selected Desensitizing OTC Products: A Systematic Review. [PDF]

, 2014
Licensed by the Creative Commons Attribution LicenseObjectives. The aim of the present study was to review the published literature in order to identify relevant studies for inclusion and to determine whether there was any evidence on the clinical ...
Talioti, E, Hill, R, Gillam, DG
core   +1 more source

Analysis of the Clinical Efficacy of Laparoscopy and Hysteroscopy in the Treatment of Tubal-Factor Infertility

Frontiers in Medicine, 2021
Objective: This study aims to investigate the clinical efficacy of laparoscopy and hysteroscopy in the treatment of tubal-factor infertility (TFI) to provide a basis for predicting postoperative pregnancy rates.Methods: The clinical data of 336 patients ...
Lei Nian, Lei Nian, De-Hong Yang, De-Hong Yang, Jie Zhang, Jie Zhang, Han Zhao, Han Zhao, Cai-Fen Zhu, Cai-Fen Zhu, Ming-Feng Dong, Ming-Feng Dong, Ying Ai, Ying Ai   +13 more
doaj   +1 more source

Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

Infectious Diseases of Poverty, 2019
Background The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies (ACTs).
Akintunde Sowunmi, Godwin Ntadom, Kazeem Akano, Folasade O. Ibironke, Adejumoke I. Ayede, Chimere Agomo, Onikepe A. Folarin, Grace O. Gbotosho, Christian Happi, Stephen Oguche, Henrietta U. Okafor, Martin Meremikwu, Philip Agomo, William Ogala, Ismaila Watila, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Wellington Oyibo, Francis Useh, Temitope Aderoyeje, Titilope M. Dokunmu, Omobolaji T. Alebiosu, Sikiru Amoo, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Chukwuebuka Okafor, Odafe Akpoborie, Bayo Fatunmbi, Elsie O. Adewoye, Nnenna M. Ezeigwe, Ayoade Oduola   +35 more
doaj   +1 more source

Efficacy and safety of pafuramidine versus pentamidine maleate for treatment of first stage sleeping sickness in a randomized, comparator-controlled, international phase 3 clinical trial [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration.
Carol A. Olson (1807531), Mintwo, Alain Fukinsia, Deo, Gratias Kambau Manesa, Sonja C. Bernhard, Bilenge, Constantin Miaka Mia, Patrick Mangoni N'tombe, Pierre Nsele Mutantu (1807651), Gabriele Pohlig, Patrick Mangoni N’tombe (1807627), Sonja C Bernhard, Alain Fukinsia Mintwo, N'tombe, Patrick Mangoni, N’tombe, Patrick Mangoni, Stephen Macharia (1807624), Kuikumbi, Florent Mbo, Mpanya, Alain, Richard R. Tidwell, Alain Mpanya, Augustin Kayeye Munungi, Blum, Johannes, Gratias Kambau Manesa Deo, Alain Fukinsia Mintwo (1807636), Gabriele Pohlig, Richard R Tidwell, Pierre Nsele Mutantu, Constantin Miaka Mia Bilenge, Gratias Kambau Manesa Deo (1807630), Patrick Mangoni N’tombe, Alfred Mpoo Mpoto, Bernhard, Sonja C., Augustin Kayeye Munungi (1807645), Tidwell, Richard R., Christian Burri (141244), Carol A Olson, Ndinga Dieyi Dituvanga, Sonja C. Bernhard (1807537), Ndinga Dieyi Dituvanga (1807648), Blaise Fungula Munungu, Burri, Christian, Munungu, Blaise Fungula, Olson, Carol A., Macharia, Stephen, Dituvanga, Ndinga Dieyi, Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge (1807513), Blaise Fungula Munungu (1807519), Mpoto, Alfred Mpoo, Christian Burri, Jose Ramon Franco, Jean-Pierre Fina Lubaki (1807546), Mutantu, Pierre Nsele, Franco, Jose Ramon, Johannes Blum, Lubaki, Jean-Pierre Fina, Gabriele Pohlig (267149), Pohlig, Gabriele, Jose Ramon Franco (1807639), Carol A. Olson, Mesu, Victor Kande Betu Ku, Alfred Mpoo Mpoto (1807534), Stephen Macharia, Alain Mpanya (267142), Amadeu Dala, Johannes Blum (141240), Dala, Amadeu, Munungi, Augustin Kayeye, Victor Kande Betu Ku Mesu (1807510), Florent Mbo Kuikumbi (1807633), Amadeu Dala (1807642), Richard R. Tidwell (148409), Florent Mbo Kuikumbi, Jean-Pierre Fina Lubaki   +71 more
core   +1 more source

Statistical methodology for the evaluation of vaccine efficacy in a phase III multi-centre trial of the RTS, S/AS01 malaria vaccine in African children. [PDF]

, 2011
BACKGROUND\ud \ud There has been much debate about the appropriate statistical methodology for the evaluation of malaria field studies and the challenges in interpreting data arising from these trials.\ud \ud METHODS\ud \ud The present paper describes ...
Amanda Leach, Bejon, P, Williamson John, Mohamed, Ali, Mohamed, A, Lievens, M, Mmbando Bruno, Lievens Marc, Williamson, John, Marc Lievens, John J Aponte, Ali Mohamed, Leach, Amanda, Bruno Mmbando, Aponte John J, Mmbando, Bruno, Philip Bejon, Bejon, Philip, Mmbando, B, Aponte, John J, Bejon Philip, Aponte, JJ, Lievens, Marc, Leach Amanda, Williamson, J, Leach, A, Mohamed Ali, John Williamson   +27 more
core   +1 more source

Clinical efficacy, efficiency and outcomes

South African Family Practice, 2004
No abstract available.
N. Ebrahim, G.A. Ogunbanjo
doaj   +1 more source