Results 121 to 130 of about 169,755 (257)

Implementing clinical ethics committees as a complex intervention: presentation of a feasibility study in community care. [PDF]

BMC Med Ethics, 2020
Magelssen M, Karlsen H, Pedersen R, Thoresen L.   +3 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A experiência do comitê de bioética de um hospital público

Revista Bioética
Resumo O objetivo deste estudo foi analisar e sistematizar a experiência do comitê de bioética do Hospital Geral de São Mateus, hospital público estadual de São Paulo.
Maridite Cristóvão Gomes de Oliveira, Reinaldo Ayer de Oliveira, Maria Cezira Fantini Nogueira-Martins   +2 more
doaj   +1 more source

Correction to: Implementing clinical ethics committees as a complex intervention: presentation of a feasibility study in community care. [PDF]

BMC Med Ethics, 2020
Magelssen M, Karlsen H, Pedersen R, Thoresen L.   +3 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Institutional challenges for clinical ethics committees

, 2011
Clinical ethics committees (CECs) have been developing in many countries since the 1980s, more recently in the transitional countries in Eastern Europe.
Jean-Philippe Cobbaut, Ana Borovecki, Stella Reiter-Theil, Borovecki, Ana, Boitte, Pierre, Reiter-Theil, Stella, Andrea Dörries, Cobbaut, Jean-Philippe, Pierre Boitte, Dörries, Andrea, Slowther, Anne, Anne-Marie Slowther, Slowther, Anne-Marie   +12 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Continuous review for ethical conduct of clinical trial-are the ethics committees complying?

Perspectives in Clinical Research
Ethics committees (ECs) play a crucial role in safeguarding clinical trial participants through ongoing review beyond initial protocol approval. Although regulations require periodic monitoring of study progress, risk, protocol adherence, and informed ...
Mrunalini Vinay Kalikar, Ganesh Dakhale
doaj   +1 more source

Clinical ethics and the role of clinical ethics committees: proposals for a revival

, 2017
The issue addressed in the paper published by the Italian National Bioethics Committee (NBC) entitled “Clinical ethics committees”, is highly significant for many reasons.
Petrini, Carlo, Ricciardi, Walter
core