Results 131 to 140 of about 169,755 (257)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Importance of Ethics Committees in Diabetes-related Clinical Research in India

Chronicle of Diabetes Research and Practice, 2022
Ravindra B. Ghooi, Shailesh R. Deshpande
doaj   +1 more source

The structure and function of research ethics committees in Africa: A case study [PDF]

, 2007
Hyder, AA, Ndossi, Godwin, Nancy E Kass, Adnan Ali Hyder, Ademola Ajuwon, John Appiah-Poku, Ajuwon Ademola, Mokhachane, Mantoa, Mupenda, B, Appiah-Poku, J, Ndebele, Paul, Barsdorf, N, Mupenda Bavon, Bavon Mupenda, Ndossi, G, Elsayed, DE, Elsayed, Dya Eldin, Mantoa Mokhachane, Kass, Nancy E., Hyder, Adnan Ali, Tindana Paulina, Kass Nancy E, Tangwa, G, Godfrey Tangwa, Appiah-Poku John, Ndebele, P, Sikateyo, Bornwell, Ndebele Paul, Tindana, Paulline, Hyder Adnan Ali, Tindana, P, Tangwa, Godfrey, Appiah-Poku, John, Kass, NE, Paul Ndebele, Ndossi Godwin, Dya Eldin Elsayed, Mokhachane, M, Sikateyo, B, Ajuwon, Ademola, Barsdorf Nicola, Mokhachane Mantoa, Sikateyo Bornwell, Paulina Tindana, Godwin Ndossi, Nicola Barsdorf, Tindana, Paulina, Ajuwon, A, Elsayed Dya Eldin, Mupenda, Bavon, Tangwa Godfrey, Bornwell Sikateyo, Barsdorf, Nicola   +52 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Is There a Place for Lawyers on Ethics Committees? a View From the Inside

, 1990
Two attorneys who serve on hospital ethics committees address arguments against the inclusion of lawyers on these committees. Mitchell and Swartz believe that participation by an ethically concerned and sensitive attorney can bring a valuable ...
Mitchell, Suzanne M., Swartz, Martha S.
core  

The New Organization of Ethics Committees in Italy: What is the Future of Clinical Ethics?

Background: In Italy, clinical ethics is not well institutionalized. On February 7, 2023, the Italian Ministry of Health published four long-awaited decrees regarding the reorganization of ethics committees.
Raimondi, Costanza, Sacchini, Dario, Refolo, Pietro, Spagnolo, Antonio Gioacchino   +3 more
core   +1 more source

Ethics and Statistical Methodology in Clinical Trials

, 1993
Statisticians in medicine can disagree on appropriate methodology applicable to the design and analysis of clinical trials. So called Bayesians and frequentists both claim ethical superiority.
Palmer, Christopher R., Palmer, Christopher   +1 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source