Results 121 to 130 of about 636,139 (316)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Evolución clínica de pacientes tratados con factor de transferencia Clinical evolution of patients treated with transfer factor

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2004
La efectividad del factor de transferencia no ha sido evaluada en investigaciones poscomercialización. Realizamos un estudio transversal y descriptivo en 9 hospitales de Ciudad de La Habana, desde abril del 2001 hasta abril del 2002, para evaluar la ...
María Aida Cruz Barrios, Blanca Nieves Rodríguez Montiel, Juan Antonio Furones Mourelle, Elisa Pérez Barrera, Alberto C Morris Abella, Santos Huete Ferreira<a name=cargo></a>   +5 more
doaj  

NADPH-Related Enzymes and Cancer: Facts and Insights Into the Application of Immunohistochemistry

Biochemistry Research International
During tumorigenesis and metastasis, cancer cells initiate antioxidant defense mechanisms to prevent irreversible damage, thereby sustaining tumor growth. The functionality of reactive oxygen species (ROS)–scavenging proteins is dependent on nicotinamide
Camila M. Scudeler, Keila Samantha da Silva, Rafaela V. N. Silva, Adilha M. R. Micheletti, Karen B. Ribeiro, Juliana Reis Machado, Régia C. P. Lira   +6 more
doaj   +1 more source

Ventricular Intramyocardial Dissecting Hematoma: What Is its True Clinical Evolution and the Best Treatment? [PDF]

JACC Case Rep, 2023
Moral S, Martinez-Ballart S, Ballesteros E, Brugada R.   +3 more
europepmc   +1 more source

Evolution and the Prevention of Violent Crime

, 2011
This paper suggests how violence prevention can be better informed by embracing an evolutionary approach to understanding and preventing violent crime. Here, ethical crime control through an evolutionary lens is consid-ered and speculation is offered as ...
Ken Pease, Pease, Kenneth, Pease, Ken, Jason Roach, Roach, Jason   +4 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Association between clinical-biological characteristics of Klebsiella pneumoniae and 28-day mortality in patients with bloodstream infection

BMC Microbiology
Background Klebsiella pneumoniae bloodstream infection (KP BSI) is a severe clinical condition characterized by high mortality rates. Despite the clinical significance, accurate predictors of mortality in KP BSI have yet to be fully identified. Methods A
Xiaofeng Yu, Yi Zhao, Xiao Sun, Jiahui Luan, Haiyan Wang, Tianyu Sun, Tongtong Lin, Xia Zhou, Wei Yang, Ziguang Deng, Bo Liu, Hongyun Cao   +11 more
doaj   +1 more source

Five-year serological and clinical evolution of chronic Chagas disease patients in Cochabamba, Bolivia. [PDF]

PLoS Negl Trop Dis, 2023
Pinto J, Skjefte M, Alonso-Padilla J, Lozano Beltran DF, Pinto LV, Casellas A, Arteaga Terrazas ME, Toledo Galindo KA, Challapa Quechover R, Escobar Caballero M, Perez Salinas A, Castellón Jimenez M, Sanz S, Gascón J, Torrico F, Pinazo MJ.   +15 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Nutrición y metabolismo en Cirugía: Conferencia Rafael Casas Morales 2009 Nutrition and metabolism in surgery Rafael Casas Morales Lecture

Revista Colombiana de Cirugía, 2009
La desnutrición tiene una prevalencia alta en los pacientes quirúrgicos y un impacto negativo en el pronóstico, y se asocia con mayores tasas de morbilidad y mortalidad; también con estancias hospitalarias más prolongadas y costos más altos para el ...
Saúl Javier Rugeles
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