Results 101 to 110 of about 636,139 (316)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Effectiveness of HoofCare® in the treatment of digital dermatitis in dairy cows

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
This study aimed to determine the effectiveness of topical HoofCare® in the treatment of digital dermatitis (DD) in dairy cows. Thirty-six high-yielding Holstein cows with DD in at least one limb were included and randomly divided into two groups, making
A.P.A. Mendonça, P.H.M. Teodoro, J.R.B. Silva, R.B.R. Moura, R. Ravetti, C.A. Rodrigues   +5 more
doaj   +1 more source

Mycobacterium ulcerans infection: Evolution in clinical management

, 2013
Mycobacterium ulcerans infection: Evolution in clinical ...
DP O'Brien (14538911), C Simpson (7747124), P Callan (13403019), A Mcdonald (13403016)   +3 more
core  

Single-Cell Transcriptomics Sheds Light on Tumor Evolution: Perspectives from City of Hope’s Clinical Trial Teams

Tumor heterogeneity is a significant factor influencing cancer treatment effectiveness and can arise from genetic, epigenetic, and phenotypic variations among cancer cells.
Patrick A. Cosgrove, Jana Portnow, Andrea H. Bild, Aritro Nath, Thanh H. Dellinger, Behnam Badie   +5 more
core   +1 more source

New paradigms in clonal evolution: punctuated equilibrium in cancer

, 2016
Evolutionary theories are themselves subject to evolution. Clonal evolution – the model that describes the initiation and progression of cancer – is entering a period of profound change, brought about largely by technological developments in genome ...
Cross, W., Graham, T.M., Wright, N.A.
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Valor prognóstico do Escore de Risco GRACE versus Escore de Risco TIMI em síndromes coronarianas agudas Valor pronóstico del score de riesgo GRACE versus score de riesgo TIMI en síndromes coronarios agudos Prognostic Value of GRACE Scores versus TIMI Score in acute coronary syndromes

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: Embora o Escore de Risco TIMI seja o mais utilizado em síndromes coronarianas agudas sem supradesnível do segmento ST (SCA), o Escore GRACE tem potencial superioridade prognóstica, pois foi criado a partir de um registro observacional, parte ...
Luis C. L. Correia, Rafael Freitas, Ana P. Bittencourt, Alexandre C. Souza, Maria C. Almeida, Jamile Leal, José Péricles Esteves   +6 more
doaj  

The Evolution of clinical endpoints in CLL

Systematic Review: The Evolution and Use of Clinical Outcome Measures in Trials in Chronic Lymphocytic Leukemia from 200 ...
Just Weemers, Prof ML De Bruin
core   +1 more source

Adapting Clinical Paradigms to the Challenges of Cancer Clonal Evolution

, 2013
Emerging evidence suggests that cancer branched evolution may affect biomarker validation, clinical outcome, and emergence of drug resistance. The changing spatial and temporal nature of cancer subclonal architecture during the disease course suggests ...
Murugaesu, Nirupa, Swanton, Charles, Chew, Su Kit   +2 more
core   +1 more source