Results 161 to 170 of about 3,612,385 (263)

Distinct brain volume abnormalities in clinical high-risk individuals: pre- and post-antipsychotic treatment. [PDF]

Psychol Med
Zheng W, Zhang L, Xu L, Wei Y, Cui H, Zhang D, Hong Y, Zhao J, Liu S, Zhang T, Tang Y, Wang J.   +11 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Predicting long-term poor outcomes in individuals at clinical high risk for psychosis using real-world clinical data: the OASIS1000 prospective study. [PDF]

World Psychiatry
Logeswaran Y, De Micheli A, Toniol I, Chen T, Melillo A, Arribas M, Livingston NR, Krakowski K, Oliver D, Stahl D, Fusar-Poli P.   +10 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Correction to "Resting-state connectivity and tobacco smoking in clinical high-risk for psychosis (NAPLS-3)". [PDF]

Gen Psychiatr
europepmc   +1 more source

Cytokine changes in clinical high risk for psychosis population following antipsychotic medication. [PDF]

Transl Psychiatry
Wei Y, Xu L, Zhang D, Zeng J, Tang X, Yi Z, Liu H, Ju M, Cui H, Tang Y, Gao J, Hu Q, Zeng L, Li C, Wang J, Zhang T.   +15 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Diazepam modulates anterior cingulate glutamate levels in people at clinical high-risk for psychosis. [PDF]

Int J Neuropsychopharmacol
Kiemes A, Livingston NR, Lukow PB, Knight S, Jelen L, Reilly T, Dima A, Nettis MA, Lythgoe DJ, Casetta C, Egerton A, Spencer T, De Micheli A, Fusar-Poli P, Grace AA, Williams SCR, McGuire P, Davies C, Stone JM, Modinos G.   +19 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source