Results 201 to 210 of about 3,612,385 (263)

Mismatch Negativity in Subjects at Clinical High Risk for Psychosis: No Evidence of Progressive Decline. [PDF]

Eur J Neurosci
Jang J, Choe E, Ha M, Kim M, Kwon JS.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Brain texture alterations predict subtle visual perceptual dysfunctions in recent onset psychosis and clinical high-risk state. [PDF]

Transl Psychiatry
Lencer R, Sprenger A, Meyhöfer I, Dannlowski U, Romer G, Kambeitz-Ilankovic L, Kambeitz J, Lichtenstein T, Rosen M, Ruhrmann S, Haas SS, Salokangas RKR, Pantelis C, Bonivento C, Schultze-Lutter F, Meisenzahl E, Brambilla P, Bertolino A, Upthegrove R, Davatzikos C, Koutsouleris N, Borgwardt S, Andreou C, Korda A, PRONIA Consortium.   +24 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Treatment Choices for Youth at Clinical High-Risk of Psychosis: Methods of an Open Trial. [PDF]

Early Interv Psychiatry
Addington J, Liu L, Braun A, Jahraus C, Brummitt K, Stowkowy J.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study. [PDF]

Mol Psychiatry
Liu S, Agartz I, Allen P, Amminger GP, Andreassen OA, Bachman P, Baeza I, Baldwin H, Bartholomeusz CF, Borgwardt S, Catalano S, Chen X, Cho KIK, Choi S, Colibazzi T, Cooper RE, Corcoran CM, Cropley VL, de Haan L, de la Fuente-Sandoval C, Dolz M, Ebdrup BH, Fortea A, Fusar-Poli P, Glenthøj LB, Glenthøj BY, Haas SS, Hamilton HK, Haut KM, Hayes RA, He Y, Heekeren K, Hegelstad WTV, Hooker CI, Horton LE, Hubl D, Hwang WJ, Kaess M, Kasai K, Katagiri N, Kim M, Kindler J, Klaunig MJ, Koike S, Kristensen TD, Kwak YB, Kwon JS, Lawrie SM, Lebedeva I, Lemmers-Jansen IL, León-Ortiz P, Lin A, Loewy RL, Ma X, Mathalon DH, McGorry P, McGuire P, Michel C, Mizrahi R, Mizuno M, Møller P, Mora-Durán R, Muñoz-Samons D, Nelson B, Nemoto T, Nordentoft M, Nordholm D, Omelchenko MA, Ouyang L, Pantelis C, Pariente JC, Raghava JM, Rasser PE, Resch F, Reyes-Madrigal F, Rivera-Chávez LF, Røssberg JI, Rössler W, Salisbury DF, Sasabayashi D, Schall U, Schiffman J, Schmidt A, Smigielski L, Sørensen ME, Sugranyes G, Suzuki M, Takahashi T, Tamnes CK, Tang J, Theodoridou A, Thomopoulos SI, Tomyshev AS, Tor J, Uhlhaas PJ, Værnes TG, van Amelsvoort TA, Velakoulis D, Via E, Vinogradov S, Waltz JA, Wenneberg C, Westlye LT, Wood SJ, Yamasue H, Yuan L, Yung AR, Chee MW, Thompson PM, Hernaus D, Jalbrzikowski M, Lee J, Zhou JH, ENIGMA Clinical High Risk for Psychosis Working Group.   +113 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Impairments in biological motion perception reflect affective disturbance in individuals at clinical high-risk for psychosis. [PDF]

Schizophr Res Cogn
Parmacek SN, Pratt DN, Mittal VA.
europepmc   +1 more source