Results 211 to 220 of about 3,612,385 (263)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Screening the Community for Individuals at Clinical High Risk (CHR) for Psychosis. [PDF]

Early Interv Psychiatry
Loch AA, Ara A, Fekih-Romdhane F, de Jesus LP, Andrade JC, Mendonça M, Serpa MH, van de Bilt MT, Gattaz WF.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Disrupted physiological coregulation in youth at clinical high risk for psychosis: Insights from a dyadic interaction study. [PDF]

Emotion
Schreiber AM, Martinez M, Li S, Williams TF, Alexander N, Mittal VA, Haase CM.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Negative symptoms and self-reflection increase alienation in individuals at clinical high-risk for psychosis. [PDF]

Front Psychiatry
Mendonça M, Haddad NM, de Jesus LP, Andrade JC, Fekih-Romdhane F, Serpa MH, van de Bilt MT, Gattaz WF, Rössler W, Loch AA.   +9 more
europepmc   +1 more source

Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis. [PDF]

Psychol Med
Mukhtar H, Zhou D, Farina EA, Saxena A, Cahill J, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Keshwan MS, Mathalon DH, Perkins DO, Stone WS, Cho YT, Powers AR, Walker EF, Woods SW.   +17 more
europepmc   +1 more source

Timeframe for Conversion to Psychosis From Individuals at Clinical High-Risk: A Quantile Regression. [PDF]

Schizophr Bull
Zhang T, Wei Y, Tang X, Xu L, Hu Y, Liu H, Wang Z, Chen T, Li C, Wang J.   +9 more
europepmc   +1 more source

A meta-analysis comparing cognitive function between individuals at clinical high-risk for psychosis and individuals at family high-risk for psychosis. [PDF]

BMC Psychiatry
Gao R, Fan M, Wei A, Liu T, Guo L, He X, Liu Z.   +6 more
europepmc   +1 more source

Incidence, Prevalence, and Stability of Remission in Individuals With Clinical High Risk for Psychosis.

JAMA Netw Open
Seitz-Holland J, Jacobs GR, Reinen J, Mathalon D, Corcoran C, Reichenberg A, Vangel M, Glynn RJ, Penzel N, Cho KK, Castro E, Haidar A, Addington JM, Kapur T, Bouix S, Bearden CE, Kane JM, McGorry PD, Woods SW, Nelson B, Kahn RS, Shenton ME, Cecchi GA, Pasternak O.   +23 more
europepmc   +1 more source