Results 211 to 220 of about 5,841,868 (306)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Timeframe for Conversion to Psychosis From Individuals at Clinical High-Risk: A Quantile Regression. [PDF]

Schizophr Bull
Zhang T, Wei Y, Tang X, Xu L, Hu Y, Liu H, Wang Z, Chen T, Li C, Wang J.   +9 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms. [PDF]

Transl Psychiatry
Williams TF, Gold JM, Waltz JA, Schiffman J, Ellman LM, Strauss GP, Walker EF, Woods SW, Powers AR, Kenney J, Pappu MK, Corlett PR, Tran T, Silverstein SM, Zinbarg RE, Mittal VA.   +15 more
europepmc   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Clinical High Risk Controversies and Challenge for the Experts [PDF]

Schizophrenia Bulletin, 2017
openaire   +2 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Incidence, Prevalence, and Stability of Remission in Individuals With Clinical High Risk for Psychosis.

JAMA Netw Open
Seitz-Holland J, Jacobs GR, Reinen J, Mathalon D, Corcoran C, Reichenberg A, Vangel M, Glynn RJ, Penzel N, Cho KK, Castro E, Haidar A, Addington JM, Kapur T, Bouix S, Bearden CE, Kane JM, McGorry PD, Woods SW, Nelson B, Kahn RS, Shenton ME, Cecchi GA, Pasternak O.   +23 more
europepmc   +1 more source

Revisiting the Defeatist Performance Belief Scale in Adults With Schizophrenia and Youth at Clinical High-Risk for Psychosis: A Comprehensive Psychometric Analysis. [PDF]

Schizophr Bull
Luther L, Ahmed AO, Grant PM, Granholm E, Gold JM, Williams TF, Pratt D, Holden J, Walker EF, Arnold L, Ellman LM, Mittal VA, Zinbarg R, Silverstein SM, Corlett PR, Powers AR, Woods SW, Waltz JA, Schiffman J, Strauss GP.   +19 more
europepmc   +1 more source