Results 41 to 50 of about 428,100 (253)

SARS-CoV-2 and dengue virus coinfection in an adult with beta-thalassemia (trait): A case report from Bangladesh with literature review

Heliyon, 2021
Introduction: Coinfections are common in pandemics, however not in recorded patients with hemoglobinopathies. The Coronavirus Disease 2019 (COVID-19) pandemic struck Bangladesh at the beginning of March 2020, which is also an apt period for endemic ...
Md Rezaul Hossain, Monira Sarmin, Hafizur Rahman, Lubaba Shahrin, Zannatun Nyma, Tahmeed Ahmed, Mohammod Jobayer Chisti   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Comparison of Common Paraclinical Tests\' Results in Semnan Province with the Global Reference Ranges: a Cross Sectional Study with High Sample Size

Medical Laboratory Journal, 2015
Background and Objective: Knowledge about normal range of tests is one of the most important parameters in correct interpretation of the results. Accordingly, we decided to determine normal range of common paraclinical tests in Semnan and compare them ...
Alavy Toussy, J, Soltany, S, Semnani, V
doaj  

Prevalence, Geographic Distribution, Risk Factors and Co-Infections of Feline Gammaherpesvirus Infections in Domestic Cats in Switzerland

Viruses, 2019
Recently, a gammaherpesvirus was described in domestic cats (FcaGHV1). The goal of the present study was to investigate the presence of FcaGHV1 in Swiss domestic cats and analyze potential risk factors.
Marilisa Novacco, Neda Ranjbar Kohan, Martina Stirn, Marina L. Meli, Adrian Alberto Díaz-Sánchez, Felicitas S. Boretti, Regina Hofmann-Lehmann   +6 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Implementation of the laboratory quality management system (ISO 15189): Experience from Bugando Medical Centre Clinical Laboratory – Mwanza, Tanzania

African Journal of Laboratory Medicine, 2018
Background: Use of laboratory evidence-based patient health care in Tanzania remains a complex problem, as with many other countries in sub-Saharan Africa.
Medard Beyanga, Lisa Gerwing-Adima, Kahima Jackson, Benjamin Majaliwa, Henrico Shimba, Simon Ezekiel, Charles Massambu, Dickson Majige, Michael Mwasegaka, Wilson Mtotela, Patrick Mateta, Christa Kasang   +11 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Evaluating the adequacy of intervals for repeat antimicrobial susceptibility testing

Annals of Clinical Microbiology
Background: The optimal frequency for repeat antimicrobial susceptibility testing (AST) of isolates of the same species remain undefined despite its importance in antimicrobial therapy.
Yu Jin Park, Xinyi Lu, Sunghyuk Kim, Shinyoung Yoon, Daewon Kim, Ki Ho Hong, Hyukmin Lee, Dongeun Yong   +7 more
doaj   +1 more source

Diagnostic challenges with accurate identification of Listeria monocytogenes isolates from food and environmental samples in South Africa

African Journal of Laboratory Medicine, 2022
Background: The 2017–2018 listeriosis outbreak in South Africa warranted testing for Listeria monocytogenes in food products and processing environments. Diagnostic tests are needed to accurately differentiate L. monocytogenes from other Listeria species.
Teena S.M. Thomas, Juno Thomas, Karren le Roux, Sanelisiwe T. Duze, Faith Mkhwanazi, Adriano Duse   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source