Results 101 to 110 of about 12,508,548 (262)

Predicting dyscalcemia using machine learning models based on routine laboratory data

Journal of Associated Medical Sciences
Background: Dyscalcemia is associated with significant clinical complications, and the demand for calcium testing is rising disproportionately. Objectives: This study aimed to develop machine learning (ML) models to predict total calcium abnormalities
Busadee Pratumvinit, Kittisak Thawnashom, Bunjira Makond   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Clinical laboratory COVID-19 response call : March 23, 2020 [PDF]

Transcript and audio file.CDC\u2019s Division of Laboratory Systems (DLS) convenes regular calls with clinical laboratories to discuss the nation\u2019s clinical laboratory response to coronavirus disease (COVID-19).

core  

Investigating the role of the mPGES-PGE₂-EP4 pathway in Escherichia coli-induced mastitis in dairy cows: insights for non-antibiotic therapeutic strategies

Frontiers in Veterinary Science
Escherichia coli (E. coli) is the primary causative agent of bovine mastitis. Currently, antibiotic therapy remains the cornerstone of mastitis treatment; necessitating the identification of alternative therapeutic options.
Xiaolin Yang, Xiaolin Yang, Xueqiang Li, Xueqiang Li, Lili Guo, Lili Guo, Pengfei Gong, Pengfei Gong, Pengfei Gong, Yinghong Qian, Shuangyi Zhang, Shuangyi Zhang, Bo Liu, Bo Liu, Wenrui Guo, Wenrui Guo, Haixia Bao, Haixia Bao, Wei Mao, Wei Mao   +19 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Clinical laboratory COVID-19 response call : April 27, 2020 [PDF]

CDC\u2019s Division of Laboratory Systems (DLS) convenes regular calls with clinical laboratories to discuss the nation\u2019s clinical laboratory response to coronavirus disease (COVID-19).

core  

[The ways of harmonization of clinical laboratory measurement techniques].

Klinicheskaia laboratornaia diagnostika, 2013
The results of implementation of different clinical laboratory techniques are to be equal in clinically significant limits to be optimally applied in diagnostics of diseases and treatment of patients. When the results of laboratory tests are not standardized and harmonized for the very same clinical assay the results can be expressed by unmatched ...
W G, Miller, G L, Myers, M L, Gantzer, S E, Kahn, E R, Schönbrunner, L M, Thienpont, D M, Bunk, R H, Christenson, J H, Eckfeldt, G L, Stanley, C M, Nubling, C M, Sturgeon   +11 more
openaire   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Clinical Laboratory COVID-19 Response Call: February 22, 2021 [PDF]

CDC\u2019s Division of Laboratory Systems (DLS) convenes regular calls with clinical laboratories to discuss the nation\u2019s clinical laboratory response to coronavirus disease (COVID-19).

core