Results 31 to 40 of about 678,144 (288)

Endogenous endophthalmitis caused by a multidrug-resistant hypervirulent Klebsiella pneumoniae strain belonging to a novel single locus variant of ST23: first case report in China

BMC Infectious Diseases, 2018
Background Endogenous endophthalmitis caused by hypervirulent Klebsiella pneumoniae (HVKP) is an emerging infectious disease commonly with a devastating visual outcome. Most HVKP strains display a wild-type susceptibility profile to antibiotics. However,
Min Xu, Ang Li, Haishen Kong, Weili Zhang, Hongchao Chen, Yajie Fu, Yiqi Fu   +6 more
doaj   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Association of hematological and biochemical tests and complications after cardiovascular surgery

O Mundo da Saúde, 2022
Cardiac surgery has postoperative complications of varying severities. Knowing the predictors of such complications can minimize risks and increase patient survival.
Sandra Leontina Graube, Karen Rafaela Okaseski, Bruna Felipin Ludvig, Silvana Agnolleto Bewanger, Vivian Lemes Lobo Bittencourt, Christiane de Fátima Colet, Eliane Roseli Winkelmann   +6 more
doaj  

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

MLKL is involved in the regulation of skin wound healing and interplay between macrophages and myofibroblasts in mice

Scientific Reports
Mixed lineage kinase domain-like protein (MLKL), a critical necroptosis effector, is strongly linked to inflammation, a key component of skin wound healing. However, its precise role in the wound healing process remains inadequately characterized.
Jiamin Zhao, Shuangyi Zhang, Yunjie Bai, Zhiguo Gong, Wenhui Bao, Zhuoya Yu, Bo Liu, Wei Mao, Surong Hasi   +8 more
doaj   +1 more source

CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

BMC Immunology, 2019
Background Immune inhibitory receptors play an important role in chronic infections. However, little is known about their role in hepatitis B virus (HBV) infection.
Yuejiao Dong, Xuefen Li, Lu Zhang, Qiaoyun Zhu, Chunlei Chen, Jiaqi Bao, Yu Chen   +6 more
doaj   +1 more source

Why Test study protocol: a UK-wide audit using the Primary Care Academic CollaboraTive (PACT) to explore the reasons for primary care testing

BJGP Open, 2022
Background: The number of blood tests done in primary care has been increasing over the past 20 years. Some estimates suggest that up to one-quarter of these tests may not have been needed.
Alexander Burrell, Polly Duncan, Ian Bennett-Britton, Sam Hodgson, Samuel WD Merriel, Salman Waqar, Penny Whiting, Jessica Watson, on behalf of the Primary Care Academic Collaborative (PACT)   +8 more
doaj   +1 more source

Laboratory techniques of veterinary clinical immunology: A review

Comparative Immunology, Microbiology and Infectious Diseases, 1981
Laboratory tests currently used or easily applicable in veterinary clinical immunology were reviewed in the following three categories: (1) tests detecting disorders in humoral immune response: serum protein screening tests, gammaglobulin estimation and complement testing; (2) tests detecting disorders in cellular immune response: phagocyte function ...
openaire   +2 more sources

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

TLR2 and NLRP3 Orchestrate Regulatory Roles in Escherichia coli Infection-Induced Septicemia in Mouse Models

Journal of Innate Immunity
Introduction: Escherichia coli (E. coli) is a significant commensal gram-negative bacterium that can give rise to various diseases. The roles of Toll-like receptor 2 (TLR2) and the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome ...
Zhiguo Gong, Wei Mao, Jiamin Zhao, Peipei Ren, Zhuoya Yu, Yunjie Bai, Chao Wang, Yuze Liu, Shuang Feng, Surong Hasi   +9 more
doaj   +1 more source