Results 51 to 60 of about 839,620 (307)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A Perspective on the Potential Role of Neuroscience in the Court [PDF]

, 2016
This Article presents some lessons learned while offering expert testimony on neuroscience in courts. As a biomedical investigator participating in cutting-edge research with clinical and mentoring responsibilities, Dr. Ruben Gur, Ph.D., became involved
Gur, Alon G., Gur, Arona E., Gur, Oren M., Gur, Ruben C.   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Integration of neuroscience into psychiatric training and practice: suggestions for implementation

BJPsych Bulletin
Mainstream psychiatric practice requires a solid grounding in neuroscience, an important part of the biopsychosocial model, allowing for holistic person-centred care.
Isabel Mark, Norman Poole, Niruj Agrawal
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Integrative neurovascular coupling and neurotransmitter analyses in anisometropic and visual deprivation amblyopia children

iScience
Summary: The association between visual abnormalities and impairments in cerebral blood flow and brain region potentially results in neural dysfunction of amblyopia. Nevertheless, the differences in the complex mechanisms of brain neural network coupling
Xiaopan Zhang, Liang Liu, Yadong Li, Xiao Li, Kejia Wang, Shaoqiang Han, Mengzhu Wang, Yong Zhang, Guangying Zheng, Jingliang Cheng, Baohong Wen   +10 more
doaj   +1 more source

Improving transparency and scientific rigor in academic publishing. [PDF]

, 2018
Progress in basic and clinical research is slowed when researchers fail to provide a complete and accurate report of how a study was designed, executed, and the results analyzed.
Alberts, Als-Nielsen, Altman, Baker, Baker, Bandrowski, Barde, Beery, Begley, Bravo, Button, Capes-Davis, Capuano, Chambers, Clayton, Clayton, Cohen, Collins, Collins, Collins, Crabbe, Dickersin, Festing, Florez-Vargas, Forstmeier, Freedman, Freedman, Fritz, Galbraith, Glasziou, Godlee, Goodman, Goodman, Hartshorne, Hoenig, Holman, Hooijmans, Ingalhalikar, Ioannidis, Jazin, Karanicolas, Kilkenny, Kilkenny, Kilkenny, Kimmelman, Laine, Landis, Lazic, Lazic, Lazic, Lazic, Levine, Lin, Macleod, Macleod, Matosin, Maxwell, McCarthy, Moher, Motulsky, Munafo, Nagele, Nayak, Nuzzo, Onwuegbuzie, Prager, Rousselet, Scargle, Schroter, Schulz, Segarra, Shamseer, Simmons, Smith, Smith, Smith, Steen, Steward, Strasak, Suresh, Tennant, Thompson, Vasilevsky, Weissgerber, Weissgerber, Weissgerber, Weissgerber, Weissgerber, Wilcox, Wilcox, Wilkinson, Wilson, Worp, Yamada, Young   +94 more
core   +3 more sources

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Patterns of childhood trauma co-occurrence and its predictivity for suicidality: A machine learning approach

iScience
Summary: Childhood trauma (CT) is a significant public health concern. The relationship between different CT patterns and suicidality remains largely undiscovered.
Wenbang Niu, Yi Feng, Shicun Xu, Xin Cui, Zhihao Ma, Yuanyuan Wang   +5 more
doaj   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source