Results 281 to 290 of about 17,262,511 (380)

A Prospective Multicenter Luminex-Based Clinical Algorithm to Define Unacceptable HLA Mismatches Before Kidney Transplantation. Consequences on Outcome, Waiting Time, and Wait List Composition

Fabian Köppen, Martina Koch, Kai Lopau, Katharina Heller, M. Luber, Bernd M. Spriewald, Kerstin Amann, Achim A. Jungbluth, Julia Weinmann‐Menke, Thomas Drasch, Jens M. Werner, Bernhard Banas, Daniel Zecher   +12 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Ethanol Ablation of Metastatic Lymph Nodes in Patients With Papillary Thyroid Carcinoma-Predictors of Clinical Outcome.

J Clin Endocrinol Metab
Frich PS, Sigstad E, Berstad AE, Opsahl EM, Fagerlid KH, Grøholt KK, Bjøro T, Hole KH, Flinder LI.   +8 more
europepmc   +1 more source

Efficacy of Minocycline Hydrochloride Aspiration Sclerotherapy for Symptomatic Simple Hepatic Cysts: Does Clinical Outcome Vary With the Number of Injections? [PDF]

Cureus
Azami T, Takano Y, Tamai N, Noda J, Niiya F, Nagahama M.   +5 more
europepmc   +1 more source

Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy.

New England Journal of Medicine, 2003
M. Maron, I. Olivotto, S. Betocchi, S. Casey, J. Lesser, M. Losi, F. Cecchi, B. Maron   +7 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Clinical outcome after entero-enteric anastomosis for Crohn's disease: a case-control study. [PDF]

J Crohns Colitis
Neri B, Schiavone SC, Mancone R, Fiorillo M, Fonsi A, Calabrese E, Perugini L, Piccione G, Di Matteo FM, Marafini I, Lolli E, Sica GS, Monteleone G, Biancone L.   +13 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Improvement and maintenance of clinical outcome assessments in atopic dermatitis with amlitelimab. [PDF]

J Eur Acad Dermatol Venereol
Blauvelt A, Chovatiya R, Merola JF, Weidinger S, Igawa K, Brookes E, Weber C, Wang J, Gray C.   +8 more
europepmc   +1 more source

Do JIA core outcome variables at baseline predict clinically inactive disease states at one year?

, 2017
Mcdonagh, Janet
openalex   +1 more source