Results 21 to 30 of about 5,379,197 (286)

The science of clinical practice: disease diagnosis or patient prognosis? Evidence about "what is likely to happen" should shape clinical practice. [PDF]

, 2015
BACKGROUND: Diagnosis is the traditional basis for decision-making in clinical practice. Evidence is often lacking about future benefits and harms of these decisions for patients diagnosed with and without disease.
A Chauffard, A Vickers, AD Hingorani, Adam Timmis, AJ Vickers, Alastair D Hay, C Mar Del, CK Lee, DA Asch, Danielle A Van Der Windt, DE Newby, Douglas G Altman, E Rosenberg Charles, E Stolper, EAM Gale, EW Steyerberg, G-J Dinant, George Peat, H Downing, H Hemingway, Harry Hemingway, HG Welch, HM Krumholz, I Roberts, Ian Roberts, Independent UK Panel on Breast Cancer Screening, J Vestbo, J Wellwood, JC Hill, JG Jarvik, Jonathan J Deeks, Jutel Annemarie Goldstein, Kate M Dunn, L Ferrante di Ruffano, Linda LeResche, M Korff Von, M Roland, Michael Sharpe, Michael Von Korff, O Bruder, P Brown, Pablo Perel, PD White, Peter Croft, PM Bossuyt, R Aronowitz, R Moynihan, R Smith-Bindman, RA Aronowitz, Richard D Riley, Richard J Stevens, RK Simmons, RO Bonow, SJ Lord, SS Watson, Steffen E Petersen, TB Murdoch, WJ Katon   +57 more
core   +4 more sources

Developing Angelman syndrome-specific clinician-reported and caregiver-reported measures to support holistic, patient-centered drug development

Orphanet Journal of Rare Diseases, 2023
Background Angelman syndrome (AS) is a rare, heterogenous neurogenetic condition, which significantly impacts the lives of people with AS and their families. Valid and reliable measures reporting key symptoms and functional impairments of AS are required
Siobhan Connor-Ahmad, Jorrit Tjeertes, Michael Chladek, Louise Newton, Tara Symonds, Susanne Clinch, Brenda Vincenzi, Fiona McDougall   +7 more
doaj   +1 more source

Burden of illness of trigeminal neuralgia among patients managed in a specialist center in England

The Journal of Headache and Pain, 2020
Background Trigeminal neuralgia (TN) causes severe episodic, unilateral facial pain and is initially treated with antiepileptic medications. For patients not responding or intolerant to medications, surgery is an option.
Lasair O’Callaghan, Lysbeth Floden, Lisa Vinikoor-Imler, Tara Symonds, Kathryn Giblin, Chris Hartford, Joanna M. Zakrzewska   +6 more
doaj   +1 more source

Comparability of a provisioned device versus bring your own device for completion of patient-reported outcome measures by participants with chronic obstructive pulmonary disease: qualitative interview findings

Journal of Patient-Reported Outcomes, 2022
Background There is interest in participants using their own smartphones or tablets (“bring your own device”; BYOD) to complete patient-reported outcome (PRO) measures in clinical studies.
Louise Newton, Oliver Knight-West, Sonya Eremenco, Stacie Hudgens, Mabel Crescioni, Tara Symonds, David S. Reasner, Bill Byrom, Paul O’Donohoe, Susan Vallow, the Patient-Reported Outcome (PRO) Consortium, Electronic Clinical Outcome Assessment (eCOA) Consortium   +11 more
doaj   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
A Mercat, AM Cheung, C Brun-Buisson, C Rossi, Cecilia M O’Kane, Christine McNally, Daniel F McAuley, DJ Kor, Excellence NIfHaC, F Gao Smith, Gavin D Perkins, GD Rubenfeld, GR Bernard, Grainne Crealey, Irish Critical Care Trials Group, John G Laffey, KF Schulz, LA Curtis, Lynn Murphy, M Shyamsundar, MA Matthay, Mark Cross, Michael Stevenson, MS Herridge, RG Brower, S Harvey, SE Erickson, T Craig, The ARDS Network investigators, The EuroQol Group, TR Craig, TW Felton   +31 more
core   +1 more source

Proceedings of the 2022 Cannabis Clinical Outcomes Research Conference

Medical Cannabis and Cannabinoids, 2022
The Consortium for Medical Marijuana Clinical Outcomes Research, a multi-university collaboration established by the state of Florida in the USA, hosted its second annual Cannabis Clinical Outcomes Research Conference (CCORC) in May 2022.
Nicole E. Smolinski, Ruba Sajdeya, Robert Cook, Yan Wang, Almut G. Winterstein, Amie Goodin   +5 more
doaj   +1 more source

Stem Cell Transplantation As A Dynamical System: Are Clinical Outcomes Deterministic? [PDF]

, 2014
Outcomes in stem cell transplantation (SCT) are modeled using probability theory. However the clinical course following SCT appears to demonstrate many characteristics of dynamical systems, especially when outcomes are considered in the context of immune
Buck, Gregory A, Chung, Harold, Clark, William, Jameson-Lee, Max, Kobulnicky, Jared D, Koparde, Vishal, Manjili, Masoud H, McCarty, John, Meier, Jeremy, Neale, Michael C, Roberts, Catherine H, Sabo, Roy T, Salman, Salman, Scalora, Allison, Serrano, Myrna, Sheth, Nihar, Toor, Amir A   +16 more
core   +3 more sources

The comparative clinical course of pregnant and non-pregnant women hospitalised with influenza A(H1N1)pdm09 infection [PDF]

, 2012
Introduction: The Influenza Clinical Information Network (FLU-CIN) was established to gather detailed clinical and epidemiological information about patients with laboratory confirmed A(H1N1)pdm09 infection in UK hospitals.
Bannister, B., Brett, S. J., Dolan, G. P., Enstone, J. E., Lim, W. S., McMenamin, J., Myles, P. R., Net, I. C. I., Nguyen-Van-Tam, J. S., Nicholson, K. G., Openshaw, P. J. M., Read, R. C., Semple, M. G., Taylor, B. L.   +13 more
core   +7 more sources

Patient‐Reported Outcome Measures for Severe Recurrent Bilateral Nasal Polyps: Psychometric Evaluation and Content Validity

OTO Open, 2023
Objective To date, no patient‐reported outcome measures have been specifically developed to assess pharmacological treatment effect in participants with severe chronic rhinosinusitis (CRS) with recurrent bilateral nasal polyps (NP).
Adam Gater, Chloe Tolley, Rebecca Williams‐Hall, Claire Trennery, Helena Bradley, Mirko V. Sikirica, Linda Nelsen, Ana R. Sousa, Daniel J. Bratton, Robert Chan, Robyn vonMaltzahn   +10 more
doaj   +1 more source

The Impact of Inter-Hospital Transfer on Clinical Outcomes following Endovascular Treatment for Acute Ischemic Stroke [PDF]

, 2019
PURPOSE Hospitals designated as primary stroke centers offer noninvasive treatment for acute ischemic stroke, but only comprehensive stroke centers are equipped to provide endovascular treatment.
Schmidt, Tyler
core   +1 more source