Next-Generation Sequencing in Infectious-Disease Diagnostics: Economic, Regulatory, and Clinical Pathways to Adoption. [PDF]
MicrobiologyopenOsei Sekyere J.
europepmc +1 more source
Clinical impact of “pure” empirical catheter ablation of slow-pathway in patients with non-ECG documented clinical on–off tachycardia [PDF]
, 2018 Shqipe Gerguri +11 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Clinical Pathways in Managing High-Caries Children with Adverse Dental Histories. [PDF]
Medicina (Kaunas)Hashemi F +3 more
europepmc +1 more source
The Association of Cell-Free LncH19 and miR-29b Expression with the PI3K/AKT/HIF-1/VEGF Pathway in Patients with Diabetic Nephropathy: In Silico Prediction and Clinical Validation [PDF]
Noha M. Abd El‐Fadeal +10 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Enhancing neuropsychological assessment clinical pathways in Parkinson's disease through the use of technology. [PDF]
Front Digit HealthLobo EH +10 more
europepmc +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Medicina y Seguridad del TrabajoDefinir el método de trabajo utilizado en el estudio de la Calidad Asistencial de accidentes de trabajo leves, siguiendo las fases del proceso (estudio del proceso desde su entrada en admisión, la historia clínica, la comunicación entre servicios ...
Carolina Gerónimo Blasco +4 more
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