Results 141 to 150 of about 951,333 (183)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Evaluating the use of diagnostic CT with flattening filter free beams for palliative radiotherapy: Dosimetric impact of scanner calibration variability

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Palliative radiotherapy comprises a significant portion of the radiation treatment workload. Volumetric‐modulated arc therapy (VMAT) improves dose conformity and, in conjunction with flattening filter free (FFF) delivery, can decrease treatment times, both of which are desirable in a population with a high probability of retreatment ...
Madeleine L. Van de Kleut, Lesley A. Buckley, Elsayed S. M. Ali   +2 more
wiley   +1 more source

Risk analysis of the Unity 1.5T MR‐Linac adapt‐to‐shape workflow

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background and Purpose The adapt‐to‐shape (ATS) workflow on the Unity MR‐Linac (Elekta AB, Stockholm, Sweden) allows for full replanning including recontouring and reoptimization5. Additional complexity to this workflow is added when the adaptation involves the use of MIM Maestro (MIM Software, Cleveland, OH) software in conjunction with ...
Jiayi Liang, Eric Aliotta, Neelam Tyagi, Paola Godoy Scripes, Nicolas Côté, Ergys Subashi, Qijie Huang, Lian Sun, Ching‐Yun Chan, Angela Ng, Theresa Wunner, Victoria Brennan, Kaveh Zakeri, James Mechalakos   +13 more
wiley   +1 more source

Evaluation of internal target volume of abdominal tumors using cine‐MRI

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction The detailed anatomy visualization with magnetic resonance (MR)‐guided radiotherapy is particularly attractive for abdominal treatments, but patient respiratory motion can compromise image quality. The “navigator technique” produces high‐quality 3D images, triggered by diaphragm displacement, in exhale phase only.
Jessica Lye, Reza Alinaghi‐Zadeh, Sandie Fisher, Nikki Shelton, Glenn Cahoon, Leah McDermott, Richard Khor, Kym Rykers, Sweet Ping Ng   +8 more
wiley   +1 more source

Using deep learning generated CBCT contours for online dose assessment of prostate SABR treatments

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Prostate Stereotactic Ablative Body Radiotherapy (SABR) is an ultra‐hypofractionated treatment where small setup errors can lead to higher doses to organs at risk (OARs). Although bowel and bladder preparation protocols reduce inter‐fraction variability, inconsistent patient adherence still results in OAR variability.
Conor Sinclair Smith, Isabelle Gagne, Karl Otto, Carter Kolbeck, Joshua Giambattista, Abraham Alexander, Sonja Murchison, Andrew Pritchard, Erika Chin   +8 more
wiley   +1 more source

Improving dose delivery in non‐coplanar cranial SRS: Stereoscopic x‐ray‐guided mitigation of table walkout errors

Journal of Applied Clinical Medical Physics, EarlyView.
Purpose Linear accelerator (LINAC)‐based single‐isocenter multi‐target (SIMT) treatment has streamlined the cranial stereotactic radiosurgery (SRS) workflow. Though efficient, SIMT delivery adds additional challenges that should be considered, including increased sensitivity to rotational errors for off‐isocenter targets.
Yohan A. Walter, Philip F. Durham, Anne N. Hubbard, William E. Burrell, Hsinshun T. Wu   +4 more
wiley   +1 more source

Implementation of needle‐tracking technology for real‐time transrectal ultrasound‐guided interstitial gynecological HDR brachytherapy: A feasibility study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To investigate the feasibility of adapting a commercial prostate biopsy system for transrectal ultrasound (TRUS)‐guided hybrid gynecological (GYN) high‐dose‐rate (HDR) brachytherapy (BT). Leveraging 3D‐TRUS and MR image fusion, the prototype system aims to improve real‐time needle placement accuracy.
Lindsey H. Bloom, Diandra Ayala‐Peacock, Rajesh Venkataraman, Brett Eckroate, Ryan Sanford, Junzo Chino, Yongbok Kim, Julie Raffi, Oana Craciunescu   +8 more
wiley   +1 more source

An investigation into the feasibility and efficacy of stereotactic radiosurgery for 1–3 cm single brain lesions on the ring‐mounted Halcyon LINAC

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose An evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1–3 cm) brain lesions. Methods After completing the extensive in‐house quality assurance checks including Winston–Lutz test and independent dose verification via MD Anderson ...
Kate Hazelwood, Shane McCarthy, Josh Misa, David Castelvetere, William St. Clair, Damodar Pokhrel   +5 more
wiley   +1 more source