Results 181 to 190 of about 8,138,914 (303)

Exploring Clinical Pathways to a Metastatic Lung Cancer Diagnosis: A Latent Class Analysis Using North Carolina Multipayer Claims Data. [PDF]

Cancer Epidemiol Biomarkers Prev
Coombs LA, Zhou X, Baggett CD, Reeder-Hayes KE, Diaz F, Weiss J, Thompson CA, Lund JL.   +7 more
europepmc   +1 more source

Capturing the variety of clinical pathways in patients with schizophrenic disorders through state sequences analysis. [PDF]

BMC Med Res Methodol, 2023
Savaré L, Ieva F, Corrao G, Lora A.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Multi-center disease-specific management system: toward standardized and harmonized clinical pathways in integrated care networks. [PDF]

Front Public Health
Liu X, Zhang R, Zheng T, Liu R, Zhang S, Zhao H, Dong J, Chen S, Xu J, Shi R.   +9 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Orthograde Apical Barrier in Non-Vital Immature Permanent Teeth: A Narrative Review of Clinical Pathways, Procedural Determinants, and Evidence Gaps. [PDF]

Dent J (Basel)
Alsayed Tolibah Y, Bshara N, Aljabban O, Kouchaji C, Lazkani T, Abbara MT, Alhaji M, Baghdadi ZD.   +7 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Inpatient Stress Test Modality and Downstream Clinical Pathways in Troponin-Negative Patients: A Real-World Cohort Study. [PDF]

Cureus
Hlupeni A, Turugari S, Murray J.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Next-Generation Sequencing in Infectious-Disease Diagnostics: Economic, Regulatory, and Clinical Pathways to Adoption. [PDF]

Microbiologyopen
Osei Sekyere J.
europepmc   +1 more source